Ocular surface neoplasias and human immunodeficiency virus infection

Jessica E. Weinstein, Carol L. Karp

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Purpose of Review: Ocular surface malignancy is a serious complication in HIV infection, but can often result in successful treatment if diagnosed appropriately. In the literature, most reviews focus on information for the ophthalmic community. Here, we provide a review of the literature with the pertinent information for the nonophthalmologist, as they are the first point of contact for most HIV patients. Recent Findings: Ocular surface squamous neoplasia (OSSN) is the most common nonpigmented ocular surface malignancy. It can be treated well with surgery or topical chemotherapy, the newest method of treatment. When presenting in young patients, a high percentage have been found to be HIV positive. Kaposi's sarcoma is an AIDS-defining malignancy and critical to diagnose. It cannot be cured, but treatment is effective for keeping it controlled. Conjunctival lymphoma can be recognized with the salmon patch appearance. External beam radiation, systemic chemotherapy, and intralesional injections are the mainstays of treatment. Summary: Ocular surface malignancy manifests significantly in the HIV population. OSSN, Kaposi's sarcoma and conjuctival lymphoma all have different clinical presentations. The capacity of the managing physician to recognize these tumours and refer to an ophthalmologist is essential for appropriate treatment.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalCurrent Opinion in Infectious Diseases
Issue number1
StatePublished - Feb 2013


  • conjunctival lymphoma
  • HIV
  • Kaposi's sarcoma
  • neoplasia
  • ocular surface

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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