Ocular rigidity evaluation after photorefractive keratectomy: An experimental study

George D. Kymionis, Vasilios F. Diakonis, George Kounis, Spyridon Charisis, Dimitrios Bouzoukis, Harilaos Ginis, Sonia H Yoo, Miltiadis Tsilimbaris, Ioannis G. Pallikaris

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Abstract

PURPOSE: To evaluate possible changes of the ocular rigidity coefficient in vivo after photorefractive keratectomy (PRK) in a series of rabbit eyes, using an invasive ocular rigidity measurement device. METHODS: Sixteen eyes of 8 rabbits were used in this study. One eye from each rabbit underwent PRK for -10.00 diopters (D) in a 5-mm optical zone (92 μm) while the fellow eye served as the control. Five weeks later, the rabbits were examined under general anesthesia. The pressure-volume relationship and the ocular rigidity coefficient were determined in all 16 eyes. by injecting 200 μL of saline solution (in increments of 4.5 μL) through the limbus into the anterior chamber, while the intraocular pressure (IOP) was continually monitored with a transducer, up to a maximum limit of 40 mmHg. Data within an IOP range of 10 to 40 mmHg were used to calculate the ocular rigidity coefficient. RESULTS: The preoperative central corneal thickness was comparable (P=.73, paired t test) in the pre-PRK eyes (mean: 347.5±17.11 μm) and control eyes (mean: 349.1±17.46 μm). No statistically significant difference was noted in measured ocular rigidity coefficient between eyes treated with PRK and control eyes (mean rigidity coefficient: 0.42±0.12 mmHg/μL [range: 0.23 to 0.56] and 0.47±0.12 mmHg/μL. [range: 0.28 to 0.62], respectively, with 95% confidence interval of the difference, lower: -0.10 to upper: 0.015. P=.121). CONCLUSIONS: Photorefractive keratectomy did not significantly alter ocular rigidity measurements in this experimental model.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalJournal of Refractive Surgery
Volume24
Issue number2
StatePublished - Feb 1 2008

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Photorefractive Keratectomy
Rabbits
Intraocular Pressure
Anterior Chamber

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Kymionis, G. D., Diakonis, V. F., Kounis, G., Charisis, S., Bouzoukis, D., Ginis, H., ... Pallikaris, I. G. (2008). Ocular rigidity evaluation after photorefractive keratectomy: An experimental study. Journal of Refractive Surgery, 24(2), 173-177.

Ocular rigidity evaluation after photorefractive keratectomy : An experimental study. / Kymionis, George D.; Diakonis, Vasilios F.; Kounis, George; Charisis, Spyridon; Bouzoukis, Dimitrios; Ginis, Harilaos; Yoo, Sonia H; Tsilimbaris, Miltiadis; Pallikaris, Ioannis G.

In: Journal of Refractive Surgery, Vol. 24, No. 2, 01.02.2008, p. 173-177.

Research output: Contribution to journalArticle

Kymionis, GD, Diakonis, VF, Kounis, G, Charisis, S, Bouzoukis, D, Ginis, H, Yoo, SH, Tsilimbaris, M & Pallikaris, IG 2008, 'Ocular rigidity evaluation after photorefractive keratectomy: An experimental study', Journal of Refractive Surgery, vol. 24, no. 2, pp. 173-177.
Kymionis GD, Diakonis VF, Kounis G, Charisis S, Bouzoukis D, Ginis H et al. Ocular rigidity evaluation after photorefractive keratectomy: An experimental study. Journal of Refractive Surgery. 2008 Feb 1;24(2):173-177.
Kymionis, George D. ; Diakonis, Vasilios F. ; Kounis, George ; Charisis, Spyridon ; Bouzoukis, Dimitrios ; Ginis, Harilaos ; Yoo, Sonia H ; Tsilimbaris, Miltiadis ; Pallikaris, Ioannis G. / Ocular rigidity evaluation after photorefractive keratectomy : An experimental study. In: Journal of Refractive Surgery. 2008 ; Vol. 24, No. 2. pp. 173-177.
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AU - Diakonis, Vasilios F.

AU - Kounis, George

AU - Charisis, Spyridon

AU - Bouzoukis, Dimitrios

AU - Ginis, Harilaos

AU - Yoo, Sonia H

AU - Tsilimbaris, Miltiadis

AU - Pallikaris, Ioannis G.

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N2 - PURPOSE: To evaluate possible changes of the ocular rigidity coefficient in vivo after photorefractive keratectomy (PRK) in a series of rabbit eyes, using an invasive ocular rigidity measurement device. METHODS: Sixteen eyes of 8 rabbits were used in this study. One eye from each rabbit underwent PRK for -10.00 diopters (D) in a 5-mm optical zone (92 μm) while the fellow eye served as the control. Five weeks later, the rabbits were examined under general anesthesia. The pressure-volume relationship and the ocular rigidity coefficient were determined in all 16 eyes. by injecting 200 μL of saline solution (in increments of 4.5 μL) through the limbus into the anterior chamber, while the intraocular pressure (IOP) was continually monitored with a transducer, up to a maximum limit of 40 mmHg. Data within an IOP range of 10 to 40 mmHg were used to calculate the ocular rigidity coefficient. RESULTS: The preoperative central corneal thickness was comparable (P=.73, paired t test) in the pre-PRK eyes (mean: 347.5±17.11 μm) and control eyes (mean: 349.1±17.46 μm). No statistically significant difference was noted in measured ocular rigidity coefficient between eyes treated with PRK and control eyes (mean rigidity coefficient: 0.42±0.12 mmHg/μL [range: 0.23 to 0.56] and 0.47±0.12 mmHg/μL. [range: 0.28 to 0.62], respectively, with 95% confidence interval of the difference, lower: -0.10 to upper: 0.015. P=.121). CONCLUSIONS: Photorefractive keratectomy did not significantly alter ocular rigidity measurements in this experimental model.

AB - PURPOSE: To evaluate possible changes of the ocular rigidity coefficient in vivo after photorefractive keratectomy (PRK) in a series of rabbit eyes, using an invasive ocular rigidity measurement device. METHODS: Sixteen eyes of 8 rabbits were used in this study. One eye from each rabbit underwent PRK for -10.00 diopters (D) in a 5-mm optical zone (92 μm) while the fellow eye served as the control. Five weeks later, the rabbits were examined under general anesthesia. The pressure-volume relationship and the ocular rigidity coefficient were determined in all 16 eyes. by injecting 200 μL of saline solution (in increments of 4.5 μL) through the limbus into the anterior chamber, while the intraocular pressure (IOP) was continually monitored with a transducer, up to a maximum limit of 40 mmHg. Data within an IOP range of 10 to 40 mmHg were used to calculate the ocular rigidity coefficient. RESULTS: The preoperative central corneal thickness was comparable (P=.73, paired t test) in the pre-PRK eyes (mean: 347.5±17.11 μm) and control eyes (mean: 349.1±17.46 μm). No statistically significant difference was noted in measured ocular rigidity coefficient between eyes treated with PRK and control eyes (mean rigidity coefficient: 0.42±0.12 mmHg/μL [range: 0.23 to 0.56] and 0.47±0.12 mmHg/μL. [range: 0.28 to 0.62], respectively, with 95% confidence interval of the difference, lower: -0.10 to upper: 0.015. P=.121). CONCLUSIONS: Photorefractive keratectomy did not significantly alter ocular rigidity measurements in this experimental model.

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