Ocular penetration of moxifloxacin 0.5% and gatifloxacin 0.3% ophthalmic solutions into the aqueous humor following topical administration prior to routine cataract surgery

Dianne H. Kim, Walter J. Stark, Terrence P. O'Brien

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A prospective, double-masked, randomized, parallel-group study (n = 25) was conducted to examine the ocular penetration of moxifloxacin 0.5% ophthalmic solution and gatifloxacin 0.3% solution into the aqueous humor following topical administration prior to routine cataract surgery. One drop of antibiotic was instilled every 10 min for four doses beginning 1 h prior to surgery. Preliminary results showed aqueous humor concentrations for moxifloxacin that were significantly greater (p < 0.01) than those for gatifloxacin.

Original languageEnglish (US)
Pages (from-to)93-94
Number of pages2
JournalCurrent Medical Research and Opinion
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Keywords

  • Antibiotics, ophthalmic
  • Cataract surgery
  • Fluoroquinolone
  • Gatifloxacin
  • Moxifloxacin

ASJC Scopus subject areas

  • Medicine(all)

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