Abstract
Objectives: The main objective of this review is to critically evaluate the present evidence regarding a relationship between ocular melanoma (OM) and cutaneous melanoma (CM). Melanomas are malignant neoplasms that develop from dendritic melanocytes that are found in the skin, eye, mucosal epithelia, and leptomeninges. While the skin is the most common site of melanoma development, these neoplasms can occur in any tissue that contains melanocytes. We review the incidence and characteristics of OM, evaluate the existent data regarding its potential relationship to CM, and provide some guidance for the dermatologist regarding the evaluation and diagnosis of this ocular tumor. Data Sources: A retrospective review of the literature. Study Selection: Studies included those relevant to disease pathogenesis and incidence, cohort studies (ie, studies evaluating the incidence of CM in patients with OM), and pertinent investigations from the dermatologic literature (ie, cases of atypical nevus syndromes). The referenced study designs and methodologies varied. Data Extraction and Synthesis: Data were extracted by 2 independent reviewers, and the main results are presented in a qualitative, descriptive manner. Conclusion: Evidence for comorbid OM and CM exists in patients with strong phenotypic expression of atypical nevi and conjunctival melanoma, although CDKN2A mutations have not been documented in patients with OM.
| Original language | English |
|---|---|
| Pages (from-to) | 1067-1073 |
| Number of pages | 7 |
| Journal | Archives of Dermatology |
| Volume | 139 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
Cite this
Ocular melanoma : A review and the relationship to cutaneous melanoma. / Hurst, Eva A.; William Harbour, J.; Cornelius, Lynn A.
In: Archives of Dermatology, Vol. 139, No. 8, 01.08.2003, p. 1067-1073.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ocular melanoma
T2 - A review and the relationship to cutaneous melanoma
AU - Hurst, Eva A.
AU - William Harbour, J.
AU - Cornelius, Lynn A.
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Objectives: The main objective of this review is to critically evaluate the present evidence regarding a relationship between ocular melanoma (OM) and cutaneous melanoma (CM). Melanomas are malignant neoplasms that develop from dendritic melanocytes that are found in the skin, eye, mucosal epithelia, and leptomeninges. While the skin is the most common site of melanoma development, these neoplasms can occur in any tissue that contains melanocytes. We review the incidence and characteristics of OM, evaluate the existent data regarding its potential relationship to CM, and provide some guidance for the dermatologist regarding the evaluation and diagnosis of this ocular tumor. Data Sources: A retrospective review of the literature. Study Selection: Studies included those relevant to disease pathogenesis and incidence, cohort studies (ie, studies evaluating the incidence of CM in patients with OM), and pertinent investigations from the dermatologic literature (ie, cases of atypical nevus syndromes). The referenced study designs and methodologies varied. Data Extraction and Synthesis: Data were extracted by 2 independent reviewers, and the main results are presented in a qualitative, descriptive manner. Conclusion: Evidence for comorbid OM and CM exists in patients with strong phenotypic expression of atypical nevi and conjunctival melanoma, although CDKN2A mutations have not been documented in patients with OM.
AB - Objectives: The main objective of this review is to critically evaluate the present evidence regarding a relationship between ocular melanoma (OM) and cutaneous melanoma (CM). Melanomas are malignant neoplasms that develop from dendritic melanocytes that are found in the skin, eye, mucosal epithelia, and leptomeninges. While the skin is the most common site of melanoma development, these neoplasms can occur in any tissue that contains melanocytes. We review the incidence and characteristics of OM, evaluate the existent data regarding its potential relationship to CM, and provide some guidance for the dermatologist regarding the evaluation and diagnosis of this ocular tumor. Data Sources: A retrospective review of the literature. Study Selection: Studies included those relevant to disease pathogenesis and incidence, cohort studies (ie, studies evaluating the incidence of CM in patients with OM), and pertinent investigations from the dermatologic literature (ie, cases of atypical nevus syndromes). The referenced study designs and methodologies varied. Data Extraction and Synthesis: Data were extracted by 2 independent reviewers, and the main results are presented in a qualitative, descriptive manner. Conclusion: Evidence for comorbid OM and CM exists in patients with strong phenotypic expression of atypical nevi and conjunctival melanoma, although CDKN2A mutations have not been documented in patients with OM.
UR - http://www.scopus.com/inward/record.url?scp=0042021703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042021703&partnerID=8YFLogxK
U2 - 10.1001/archderm.139.8.1067
DO - 10.1001/archderm.139.8.1067
M3 - Article
C2 - 12925397
AN - SCOPUS:0042021703
VL - 139
SP - 1067
EP - 1073
JO - JAMA Dermatology
JF - JAMA Dermatology
SN - 2168-6068
IS - 8
ER -