Ocular Manifestations of ANCA-associated Vasculitis

Anup A. Kubal, Victor L. Perez

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides-Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome-can present with various ophthalmic manifestations. In a subset of patients, these findings may be the earliest indicators of systemic disease. Orbital and anterior segment findings are most common, whereas posterior segment complications such as retinal vasculitis and optic neuropathy occur much less frequently. This article describes the distinguishing features of associated ophthalmic disease, focusing on the manifestations clinicians are most likely to encounter and those with the most significant ocular morbidity. Although the ANCA-associated vasculitides require systemic workup and treatment, this article discusses diagnostic and therapeutic modalities often used concurrently for ophthalmic disease.

Original languageEnglish (US)
Pages (from-to)573-586
Number of pages14
JournalRheumatic Disease Clinics of North America
Issue number3
StatePublished - Aug 1 2010


  • Antineutrophil cytoplasmic antibody
  • Churg-Strauss syndrome
  • Microscopic polyangiitis
  • Wegener's granulomatosis

ASJC Scopus subject areas

  • Rheumatology


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