Ocular immunity and inflammation

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Complex immunologic mechanisms are involved in multiple intraocular diseases. The field of immunology has aided greatly in better understanding and treating inflammation in the posterior segment. While traditional therapy has relied on drugs such as corticosteroids and antimetabolites that exert there effects by multiple mechanisms, the more recently developed biologic immune modulators involve specific mechanisms of action with the potential to significantly reduce side effects relative to more traditional agents. Better understanding of diseases such as age-related macular degeneration or diabetic retinopathy has led to the appreciation of immune mechanisms involved in these diseases and has suggested potential targets for therapy.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalDevelopments in Ophthalmology
Volume55
DOIs
StatePublished - 2015

Fingerprint

Immunity
Inflammation
Antimetabolites
Macular Degeneration
Diabetic Retinopathy
Allergy and Immunology
Action Potentials
Adrenal Cortex Hormones
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular immunity and inflammation. / Albini, Thomas A; Davis, Janet L.

In: Developments in Ophthalmology, Vol. 55, 2015, p. 38-45.

Research output: Contribution to journalArticle

@article{0d5ebd91a0a5481ab33362c9ec5a0e88,
title = "Ocular immunity and inflammation",
abstract = "Complex immunologic mechanisms are involved in multiple intraocular diseases. The field of immunology has aided greatly in better understanding and treating inflammation in the posterior segment. While traditional therapy has relied on drugs such as corticosteroids and antimetabolites that exert there effects by multiple mechanisms, the more recently developed biologic immune modulators involve specific mechanisms of action with the potential to significantly reduce side effects relative to more traditional agents. Better understanding of diseases such as age-related macular degeneration or diabetic retinopathy has led to the appreciation of immune mechanisms involved in these diseases and has suggested potential targets for therapy.",
author = "Albini, {Thomas A} and Davis, {Janet L}",
year = "2015",
doi = "10.1159/000431131",
language = "English (US)",
volume = "55",
pages = "38--45",
journal = "Developments in Ophthalmology",
issn = "0250-3751",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Ocular immunity and inflammation

AU - Albini, Thomas A

AU - Davis, Janet L

PY - 2015

Y1 - 2015

N2 - Complex immunologic mechanisms are involved in multiple intraocular diseases. The field of immunology has aided greatly in better understanding and treating inflammation in the posterior segment. While traditional therapy has relied on drugs such as corticosteroids and antimetabolites that exert there effects by multiple mechanisms, the more recently developed biologic immune modulators involve specific mechanisms of action with the potential to significantly reduce side effects relative to more traditional agents. Better understanding of diseases such as age-related macular degeneration or diabetic retinopathy has led to the appreciation of immune mechanisms involved in these diseases and has suggested potential targets for therapy.

AB - Complex immunologic mechanisms are involved in multiple intraocular diseases. The field of immunology has aided greatly in better understanding and treating inflammation in the posterior segment. While traditional therapy has relied on drugs such as corticosteroids and antimetabolites that exert there effects by multiple mechanisms, the more recently developed biologic immune modulators involve specific mechanisms of action with the potential to significantly reduce side effects relative to more traditional agents. Better understanding of diseases such as age-related macular degeneration or diabetic retinopathy has led to the appreciation of immune mechanisms involved in these diseases and has suggested potential targets for therapy.

UR - http://www.scopus.com/inward/record.url?scp=84947212425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947212425&partnerID=8YFLogxK

U2 - 10.1159/000431131

DO - 10.1159/000431131

M3 - Article

C2 - 26501148

AN - SCOPUS:84947212425

VL - 55

SP - 38

EP - 45

JO - Developments in Ophthalmology

JF - Developments in Ophthalmology

SN - 0250-3751

ER -