Abstract
Complex immunologic mechanisms are involved in multiple intraocular diseases. The field of immunology has aided greatly in better understanding and treating inflammation in the posterior segment. While traditional therapy has relied on drugs such as corticosteroids and antimetabolites that exert there effects by multiple mechanisms, the more recently developed biologic immune modulators involve specific mechanisms of action with the potential to significantly reduce side effects relative to more traditional agents. Better understanding of diseases such as age-related macular degeneration or diabetic retinopathy has led to the appreciation of immune mechanisms involved in these diseases and has suggested potential targets for therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 38-45 |
| Number of pages | 8 |
| Journal | Developments in Ophthalmology |
| Volume | 55 |
| DOIs | |
| State | Published - 2015 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Ocular immunity and inflammation. / Albini, Thomas A; Davis, Janet L.
In: Developments in Ophthalmology, Vol. 55, 2015, p. 38-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ocular immunity and inflammation
AU - Albini, Thomas A
AU - Davis, Janet L
PY - 2015
Y1 - 2015
N2 - Complex immunologic mechanisms are involved in multiple intraocular diseases. The field of immunology has aided greatly in better understanding and treating inflammation in the posterior segment. While traditional therapy has relied on drugs such as corticosteroids and antimetabolites that exert there effects by multiple mechanisms, the more recently developed biologic immune modulators involve specific mechanisms of action with the potential to significantly reduce side effects relative to more traditional agents. Better understanding of diseases such as age-related macular degeneration or diabetic retinopathy has led to the appreciation of immune mechanisms involved in these diseases and has suggested potential targets for therapy.
AB - Complex immunologic mechanisms are involved in multiple intraocular diseases. The field of immunology has aided greatly in better understanding and treating inflammation in the posterior segment. While traditional therapy has relied on drugs such as corticosteroids and antimetabolites that exert there effects by multiple mechanisms, the more recently developed biologic immune modulators involve specific mechanisms of action with the potential to significantly reduce side effects relative to more traditional agents. Better understanding of diseases such as age-related macular degeneration or diabetic retinopathy has led to the appreciation of immune mechanisms involved in these diseases and has suggested potential targets for therapy.
UR - http://www.scopus.com/inward/record.url?scp=84947212425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947212425&partnerID=8YFLogxK
U2 - 10.1159/000431131
DO - 10.1159/000431131
M3 - Article
C2 - 26501148
AN - SCOPUS:84947212425
VL - 55
SP - 38
EP - 45
JO - Developments in Ophthalmology
JF - Developments in Ophthalmology
SN - 0250-3751
ER -