Ocular delivery of acetylsalicylic acid by repetitive coulomb-controlled iontophoresis

Martina T. Kralinger, Monika Voigt, Gerhard F. Kieselbach, Duco Hamasaki, Brandy C. Hayden, Jean-Marie A Parel

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

To investigate the potential of transscleral coulomb-controlled iontophoresis (CCI) for repetitive delivery of acetylsalicylic acid (ASA) into the eye, a total of 50 rabbits was included in this study. Fourteen animals received serial CCI treatment. Fourteen animals underwent CCI with either ASA or balanced salt solution (BSS) for at least 6 days at 24- and 48-hour intervals. Eighteen animals received a single CCI application, while 18 animals were injected with 15 mg ASA/kg body weight intravenously. HPLC analysis was performed to determine the levels of salicylic acid (SA) in ocular tissues. Apart from clinical follow-up, 2 rabbits in the ASA and BSS groups were examined by electroretinography, and 2 animals were examined histologically. Though high concentrations of SA were measured, no alterations were observed clinically, histologically and electrophysiologically. Repetitive CCI demonstrated its potential as a topical drug delivery system for ASA into the eye. This transscleral delivery of ASA resulted in significant and sustained intraocular concentrations of SA without side effects. Iontophoresis may be advantageous in clinical administration maintaining therapeutic levels of ASA while avoiding adverse effects associated with the systemic administration of nonsteroidal anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalOphthalmic Research
Volume35
Issue number2
DOIs
StatePublished - Apr 1 2003

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Keywords

  • Acetylsalicylic acid
  • Coulomb-controlled iontophoresis
  • Electroretinography
  • Histology
  • Repetitive administration

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Kralinger, M. T., Voigt, M., Kieselbach, G. F., Hamasaki, D., Hayden, B. C., & Parel, J-M. A. (2003). Ocular delivery of acetylsalicylic acid by repetitive coulomb-controlled iontophoresis. Ophthalmic Research, 35(2), 102-110. https://doi.org/10.1159/000069129