Octreotide scintigraphy for the detection of paragangliomas

Fred F Telischi, Res Bustillo, Michelle L H Whiteman, Aldo N Serafini, Michael J. Reisberg, Orlando W Gomez-Marin, Francisco Civantos, Thomas J. Balkany

Research output: Contribution to journalArticle

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Abstract

Paragangliomas are neuroendocrine tumors located primarily in the head and neck region, but they can also occur at other sites. Confirming the preoperative diagnosis and detecting synchronous tumors may be difficult in some patients. Octreotide is a somatostatin analog that, when coupled to a radioisotope, produces a scintigraphic image of tumors expressing somatostatin type 2 receptors. Paragangliomas, like many neuroendocrine tumors, have been found to have a high density of somatostatin type 2 receptors on the cell surface. This study compared the results of preoperative octreotide scintigraphy with the histopathology in 21 patients who underwent surgery for presumed head and neck paragangliomas. Octreotide scan findings were positive in 16 patients with paragangliomas and negative in 3 patients with other pathology. One false-positive and 1 false-negative result were obtained. Thus, this test had an accuracy of 90%, a sensitivity of 94%, and a specificity of 75%. Previously unidentified synchronous tumors were identified in 5 patients. On the basis of this series of patients, octreotide scintigraphy appears to be a reliable test to detect paragangliomas and may be quite helpful in preoperative planning.

Original languageEnglish
Pages (from-to)358-362
Number of pages5
JournalOtolaryngology - Head and Neck Surgery
Volume122
Issue number3
StatePublished - Mar 28 2000

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Paraganglioma
Octreotide
Radionuclide Imaging
Neuroendocrine Tumors
Neck
Head
Neoplasms
Somatostatin
Radioisotopes
Pathology

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Telischi, F. F., Bustillo, R., Whiteman, M. L. H., Serafini, A. N., Reisberg, M. J., Gomez-Marin, O. W., ... Balkany, T. J. (2000). Octreotide scintigraphy for the detection of paragangliomas. Otolaryngology - Head and Neck Surgery, 122(3), 358-362.

Octreotide scintigraphy for the detection of paragangliomas. / Telischi, Fred F; Bustillo, Res; Whiteman, Michelle L H; Serafini, Aldo N; Reisberg, Michael J.; Gomez-Marin, Orlando W; Civantos, Francisco; Balkany, Thomas J.

In: Otolaryngology - Head and Neck Surgery, Vol. 122, No. 3, 28.03.2000, p. 358-362.

Research output: Contribution to journalArticle

Telischi, FF, Bustillo, R, Whiteman, MLH, Serafini, AN, Reisberg, MJ, Gomez-Marin, OW, Civantos, F & Balkany, TJ 2000, 'Octreotide scintigraphy for the detection of paragangliomas', Otolaryngology - Head and Neck Surgery, vol. 122, no. 3, pp. 358-362.
Telischi FF, Bustillo R, Whiteman MLH, Serafini AN, Reisberg MJ, Gomez-Marin OW et al. Octreotide scintigraphy for the detection of paragangliomas. Otolaryngology - Head and Neck Surgery. 2000 Mar 28;122(3):358-362.
Telischi, Fred F ; Bustillo, Res ; Whiteman, Michelle L H ; Serafini, Aldo N ; Reisberg, Michael J. ; Gomez-Marin, Orlando W ; Civantos, Francisco ; Balkany, Thomas J. / Octreotide scintigraphy for the detection of paragangliomas. In: Otolaryngology - Head and Neck Surgery. 2000 ; Vol. 122, No. 3. pp. 358-362.
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