Octreotide Is Ineffective in Treating Tumor-Induced Osteomalacia: Results of a Short-Term Therapy

Diana Ovejero, Diala El-Maouche, Beth A. Brillante, Azar Khosravi, Rachel I. Gafni, Michael T. Collins

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome in which unregulated hypersecretion of fibroblast growth factor 23 (FGF23) by phosphaturic mesenchymal tumors (PMT) causes renal phosphate wasting, hypophosphatemia, and osteomalacia. The resulting mineral homeostasis abnormalities and skeletal manifestations can be reversed with surgical resection of the tumor. Unfortunately, PMTs are often difficult to locate, and medical treatment with oral phosphate and vitamin D analogues is either insufficient to manage the disease or not tolerated. Octreotide has been proposed as a potential treatment for TIO due to the presence of somatostatin receptors (SSTR) on PMTs; however, the role of somatostatin signaling in PMTs and the efficacy of treatment of TIOs with somatostatin analogues is not clear. In an effort to evaluate the efficacy of octreotide therapy in TIO, five subjects with TIO were treated with octreotide for 3 days. Blood intact FGF23, phosphate, and 1,25(OH)2D3, and tubular reabsorption of phosphate (TRP) were measured at frequent time points during treatment. Octreotide's effects were assessed by comparing group means of the biochemical parameters at each time-point to mean baseline values. There were no significant changes in blood phosphate, FGF23, 1,25(OH)2D3, or TRP during octreotide treatment, consistent with a lack of efficacy of octreotide in treating TIO.

Original languageEnglish (US)
Pages (from-to)1667-1671
Number of pages5
JournalJournal of Bone and Mineral Research
Volume32
Issue number8
DOIs
StatePublished - Aug 2017

Keywords

  • CANCER
  • CELL/TISSUE SIGNALING
  • DISEASES AND DISORDERS OF/RELATED TO BONE
  • ENDOCRINE PATHWAYS
  • OSTEOMALACIA AND RICKETS
  • PTH/VIT D/FGF23
  • TUMOR-INDUCED BONE DISEASE

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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  • Cite this

    Ovejero, D., El-Maouche, D., Brillante, B. A., Khosravi, A., Gafni, R. I., & Collins, M. T. (2017). Octreotide Is Ineffective in Treating Tumor-Induced Osteomalacia: Results of a Short-Term Therapy. Journal of Bone and Mineral Research, 32(8), 1667-1671. https://doi.org/10.1002/jbmr.3162