Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor

Fatta B. Nahab, Adrian Handforth, Tyler Brown, Christopher Shin, Arnulfo Quesada, Chuanhui Dong, Dietrich Haubenberger, Mark Hallett

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.

Original languageEnglish (US)
Pages (from-to)635-638
Number of pages4
JournalNeurotherapeutics
Volume9
Issue number3
DOIs
StatePublished - Jul 2012

Keywords

  • 1-octanol
  • Essential tremor
  • Harmaline
  • Octanoic acid
  • Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Pharmacology

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