Obstructive sleep apnea phenotypes and markers of vascular disease: A review

Research output: Contribution to journalShort survey

3 Citations (Scopus)

Abstract

Obstructive sleep apnea (OSA) is a chronic and heterogeneous disorder that leads to early mortality, stroke, and cardiovascular disease (CVD). OSA is defined by the apnea-hypopnea index, which is an index of OSA severity that combines apneas (pauses in breathing) and hypopneas (partial obstructions in breathing) associated with hypoxemia. Yet, other sleep metrics (i.e., oxygen nadir, arousal frequency), along with clinical symptoms and molecular markers could be better predictors of stroke and CVD outcomes in OSA. The recent focus on personalized medical care introduces the possibility of a unique approach to the treatment of OSA based on its phenotypes, defined by pathophysiological mechanisms and/or clinical presentation. We summarized what is known about OSA and its phenotypes, and review the literature on factors or intermediate markers that could increase stroke risk and CVD in patients with OSA. The OSA phenotypes where divided across three different domains (1) clinical symptoms (i.e., daytime sleepiness), (2) genetic/molecular markers, and (3) experimental data-driven approach (e.g., cluster analysis). Finally, we further highlight gaps in the literature framing a research agenda.

Original languageEnglish (US)
Article number659
JournalFrontiers in Neurology
Volume8
Issue numberDEC
DOIs
StatePublished - Dec 5 2017

Fingerprint

Obstructive Sleep Apnea
Vascular Diseases
Phenotype
Cardiovascular Diseases
Stroke
Apnea
Respiration
Arousal
Genetic Markers
Cluster Analysis
Sleep
Oxygen
Mortality
Research

Keywords

  • Cardiovascular disease
  • Obstructive sleep apnea
  • Phenotype
  • Sleep disordered breathing
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

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abstract = "Obstructive sleep apnea (OSA) is a chronic and heterogeneous disorder that leads to early mortality, stroke, and cardiovascular disease (CVD). OSA is defined by the apnea-hypopnea index, which is an index of OSA severity that combines apneas (pauses in breathing) and hypopneas (partial obstructions in breathing) associated with hypoxemia. Yet, other sleep metrics (i.e., oxygen nadir, arousal frequency), along with clinical symptoms and molecular markers could be better predictors of stroke and CVD outcomes in OSA. The recent focus on personalized medical care introduces the possibility of a unique approach to the treatment of OSA based on its phenotypes, defined by pathophysiological mechanisms and/or clinical presentation. We summarized what is known about OSA and its phenotypes, and review the literature on factors or intermediate markers that could increase stroke risk and CVD in patients with OSA. The OSA phenotypes where divided across three different domains (1) clinical symptoms (i.e., daytime sleepiness), (2) genetic/molecular markers, and (3) experimental data-driven approach (e.g., cluster analysis). Finally, we further highlight gaps in the literature framing a research agenda.",
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AU - Ramos, Alberto

AU - Figueredo, Pedro

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AU - Dib, Salim

AU - Torre, Carlos

AU - Wallace, Douglas

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