Obsessive-Compulsive Symptoms, Polygenic Risk Score, and Thalamic Development in Children From the Brazilian High-Risk Cohort for Mental Conditions (BHRCS)

Ana Beatriz Ravagnani Salto, Marcos L. Santoro, Marcelo Q. Hoexter, Andrea Parolin Jackowski, Pedro M. Pan, Maria Conceição Rosário, Sintia I. Belangero, Pedro Gomes Alvarenga, Victoria Fogaça Doretto, Afonso Mazine Tiago Fumo, Marcelo C. Batistuzzo, Pedro Macul Ferreira de Barros, Kiara R. Timpano, Vanessa K. Ota, Luis Augusto Rohde, Euripedes Constantino Miguel, James F. Leckman, André Zugman

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Thalamic volume measures have been linked to obsessive-compulsive disorder (OCD) in children and adolescents. However, it is unclear if alterations in thalamic volumes occur before or after symptom onset and if there is a relation to the presence of sub-clinical obsessive-compulsive symptoms (OCS). Here, we explore the relationship between OCS and the rate of thalamic volume change in a cohort of children and youth at high risk to develop a mental disorder. A secondary aim was to determine if there is a relationship between OCS and the individual's OCD polygenic risk score (OCD-PRS) and between the rate of thalamic volume change and the OCD-PRS. Methods: The sample included 378 children enrolled in the longitudinal Brazilian High-Risk Cohort for Mental Conditions. Participants were assessed for OCS and the symmetrized percent change (SPC) of thalamic volume across two time-points separated by 3 years, along with the OCD-PRS. Zero-altered negative binomial models were used to analyze the relationship between OCS and thalamic SPC. Multiple linear regressions were used to examine the relationship between thalamic SPC and OCD-PRS. Results: A significant relationship between OCS and the right thalamus SPC (p = 0.042) was found. There was no significant relationship between changes in thalamic volume SPC and OCD-PRS. Conclusions: The findings suggest that changes in the right thalamic volume over the course of 3 years in children may be associated to OCS. Future studies are needed to confirm these results and further characterize the specific nature of OCS symptoms associated with thalamic volumes.

Original languageEnglish (US)
Article number673595
JournalFrontiers in Psychiatry
Volume12
DOIs
StatePublished - Jun 7 2021

Keywords

  • MRI
  • OCD-PRS
  • neuroimaging
  • obsessive-compulsive disorder
  • obsessive-compulsive symptoms
  • polygenic risk score
  • thalamus

ASJC Scopus subject areas

  • Psychiatry and Mental health

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