Abstract
The study aimed to examine the course of obsessive-compulsive disorder (OCD) across pregnancy and its impact on obstetric and neonatal outcomes. Women enrolled prior to 20-week gestation in a prospective, observational study. The Structured Clinical Interview for DSM-IV was completed to obtain lifetime Axis I diagnoses. A total of 56 women with OCD were followed at 1 to 3-month intervals through 52 weeks postpartum. Each visit, the Yale-Brown Obsessive Compulsive Scale (YBOCS), clinical assessment, and medication/exposure tracking were performed. Obstetric and neonatal data were abstracted from the medical record. In subjects with OCD, associations between perinatal obsessive-compulsive symptoms (OCSs) and outcomes were examined. Additionally, outcomes were compared to 156 matched psychiatric patients without OCD. Maternal age inversely correlated with the YBOCS scores across the study period (β = −0.5161, p =.0378). Cesarean section was associated with increased OCSs in the postpartum period compared to vaginal delivery (β = 5.3632, p = 0.043). No associations were found between severity of perinatal obsessions or compulsions and any specific obstetric or neonatal complications. Subjects without OCD had higher frequency of fetal loss compared to mothers with OCD (χ2 = 4.03, p = 0.043). These novel prospective data fail to identify an association of OCSs with adverse outcomes. In contrast, there is an association of delivery method and younger maternal age with increased postnatal symptoms of OCD. Psychiatric subjects without OCD may have a higher risk of miscarriage and intrauterine fetal demise compared to subjects with OCD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3-10 |
| Number of pages | 8 |
| Journal | Archives of Women's Mental Health |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2016 |
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Keywords
- Course of illness
- Neonatal outcomes
- Obsessive-compulsive disorder
- Obstetrical outcomes
ASJC Scopus subject areas
- Psychiatry and Mental health
- Obstetrics and Gynecology
Cite this
Obsessive-compulsive disorder in pregnancy and the postpartum period : course of illness and obstetrical outcome. / House, Samuel J.; Tripathi, Shanti P.; Knight, Bettina T.; Morris, Natalie; Newport, Donald J; Stowe, Zachary N.
In: Archives of Women's Mental Health, Vol. 19, No. 1, 01.02.2016, p. 3-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obsessive-compulsive disorder in pregnancy and the postpartum period
T2 - course of illness and obstetrical outcome
AU - House, Samuel J.
AU - Tripathi, Shanti P.
AU - Knight, Bettina T.
AU - Morris, Natalie
AU - Newport, Donald J
AU - Stowe, Zachary N.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - The study aimed to examine the course of obsessive-compulsive disorder (OCD) across pregnancy and its impact on obstetric and neonatal outcomes. Women enrolled prior to 20-week gestation in a prospective, observational study. The Structured Clinical Interview for DSM-IV was completed to obtain lifetime Axis I diagnoses. A total of 56 women with OCD were followed at 1 to 3-month intervals through 52 weeks postpartum. Each visit, the Yale-Brown Obsessive Compulsive Scale (YBOCS), clinical assessment, and medication/exposure tracking were performed. Obstetric and neonatal data were abstracted from the medical record. In subjects with OCD, associations between perinatal obsessive-compulsive symptoms (OCSs) and outcomes were examined. Additionally, outcomes were compared to 156 matched psychiatric patients without OCD. Maternal age inversely correlated with the YBOCS scores across the study period (β = −0.5161, p =.0378). Cesarean section was associated with increased OCSs in the postpartum period compared to vaginal delivery (β = 5.3632, p = 0.043). No associations were found between severity of perinatal obsessions or compulsions and any specific obstetric or neonatal complications. Subjects without OCD had higher frequency of fetal loss compared to mothers with OCD (χ2 = 4.03, p = 0.043). These novel prospective data fail to identify an association of OCSs with adverse outcomes. In contrast, there is an association of delivery method and younger maternal age with increased postnatal symptoms of OCD. Psychiatric subjects without OCD may have a higher risk of miscarriage and intrauterine fetal demise compared to subjects with OCD.
AB - The study aimed to examine the course of obsessive-compulsive disorder (OCD) across pregnancy and its impact on obstetric and neonatal outcomes. Women enrolled prior to 20-week gestation in a prospective, observational study. The Structured Clinical Interview for DSM-IV was completed to obtain lifetime Axis I diagnoses. A total of 56 women with OCD were followed at 1 to 3-month intervals through 52 weeks postpartum. Each visit, the Yale-Brown Obsessive Compulsive Scale (YBOCS), clinical assessment, and medication/exposure tracking were performed. Obstetric and neonatal data were abstracted from the medical record. In subjects with OCD, associations between perinatal obsessive-compulsive symptoms (OCSs) and outcomes were examined. Additionally, outcomes were compared to 156 matched psychiatric patients without OCD. Maternal age inversely correlated with the YBOCS scores across the study period (β = −0.5161, p =.0378). Cesarean section was associated with increased OCSs in the postpartum period compared to vaginal delivery (β = 5.3632, p = 0.043). No associations were found between severity of perinatal obsessions or compulsions and any specific obstetric or neonatal complications. Subjects without OCD had higher frequency of fetal loss compared to mothers with OCD (χ2 = 4.03, p = 0.043). These novel prospective data fail to identify an association of OCSs with adverse outcomes. In contrast, there is an association of delivery method and younger maternal age with increased postnatal symptoms of OCD. Psychiatric subjects without OCD may have a higher risk of miscarriage and intrauterine fetal demise compared to subjects with OCD.
KW - Course of illness
KW - Neonatal outcomes
KW - Obsessive-compulsive disorder
KW - Obstetrical outcomes
UR - http://www.scopus.com/inward/record.url?scp=84955577613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955577613&partnerID=8YFLogxK
U2 - 10.1007/s00737-015-0542-z
DO - 10.1007/s00737-015-0542-z
M3 - Article
VL - 19
SP - 3
EP - 10
JO - Archives of Women's Mental Health
JF - Archives of Women's Mental Health
SN - 1434-1816
IS - 1
ER -