Objectively measured sedentary time and cardiometabolic biomarkers in US Hispanic/Latino adults: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Qibin Qi, Garrett Strizich, Gina Merchant, Daniela Sotres-Alvarez, Christina Buelna, Sheila F. Castañeda, Linda C. Gallo, Jianwen Cai, Marc D. Gellman, Carmen R. Isasi, Ashley E. Moncrieft, Lisa Sanchez-Johnsen, Neil Schneiderman, Robert C. Kaplan

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Background - Sedentary behavior is recognized as a distinct construct from lack of moderate-vigorous physical activity and is associated with deleterious health outcomes. Previous studies have primarily relied on self-reported data, whereas data on the relationship between objectively measured sedentary time and cardiometabolic biomarkers are sparse, especially among US Hispanics/Latinos. Methods and Results - We examined associations of objectively measured sedentary time (via Actical accelerometers for 7 days) and multiple cardiometabolic biomarkers among 12 083 participants, aged 18 to 74 years, from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos of diverse backgrounds (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) were recruited from 4 US cities between 2008 and 2011. Sedentary time (<100 counts/min) was standardized to 16 hours/d of wear time. The mean sedentary time was 11.9 hours/d (74% of accelerometer wear time). After adjustment for moderate-vigorous physical activity and confounding variables, prolonged sedentary time was associated with decreased high-density lipoprotein cholesterol (P=0.04), and increased triglycerides, 2-hour glucose, fasting insulin, and homeostatic model assessment of insulin resistance (all P<0.0001). These associations were generally consistent across age, sex, Hispanic/Latino backgrounds, and physical activity levels. Even among individuals meeting physical activity guidelines, sedentary time was detrimentally associated with several cardiometabolic biomarkers (diastolic blood pressure, high-density lipoprotein cholesterol, fasting and 2-hour glucose, fasting insulin and homeostatic model assessment of insulin resistance; all P<0.05). Conclusions - Our large population-based, objectively derived data showed deleterious associations between sedentary time and cardiometabolic biomarkers, independent of physical activity, in US Hispanics/Latinos. Our findings emphasize the importance of reducing sedentary behavior for the prevention of cardiometabolic diseases, even in those who meet physical activity recommendations.

Original languageEnglish (US)
Pages (from-to)1560-1569
Number of pages10
JournalCirculation
Volume132
Issue number16
DOIs
StatePublished - Oct 20 2015

Keywords

  • Hispanic Americans
  • cardiovascular diseases
  • epidemiology
  • risk factors
  • sedentary lifestyle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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