Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC

Riccardo Lencioni, Robert Montal, Ferran Torres, Joong Won Park, Thomas Decaens, Jean Luc Raoul, Masatoshi Kudo, Charissa Chang, José Ríos, Valerie Boige, Eric Assenat, Yoon Koo Kang, Ho Yeong Lim, Ian Walters, Josep M. Llovet

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61 Scopus citations

Abstract

Background & Aims The Modified Response Evaluation Criteria in Solid Tumors (mRECIST) was developed to overcome the limitations of standard RECIST criteria in response assessment of hepatocellular carcinoma (HCC). We aimed to investigate whether objective response by mRECIST accurately predicted overall survival (OS) in patients with advanced HCC treated with systemic targeted therapies and also to preliminarily assess this end-point as a potential surrogate of OS. Methods Individual patient data from the BRISK-PS randomized phase III trial comparing brivanib vs. placebo (the first to prospectively incorporate mRECIST) were used to analyze objective response as a predictor of OS in a time-dependent covariate analysis. Patients with available imaging scans during follow-up were included (n = 334; 85% of those randomized). Moreover, a correlation of the survival probability in deciles vs. the observed objective response was performed to evaluate its suitability as a surrogate end-point. Results Objective response was observed in 11.5% and 1.9% of patients treated with brivanib and placebo respectively, and was associated with a better survival (median OS 15.0 vs. 9.4 months, p <0.001). In addition, objective response had an independent prognostic value (HR = 0.48; 95% confidence interval [CI], 0.26–0.91, p = 0.025) along with known prognostic factors. Finally, objective response showed promising results as a surrogate of OS in this trial (R = −0.92; 95% CI, −1 to −0.73, p <0.001). It was an early indicator of the treatment effect (median time to objective response was 1.4 months). Conclusions Objective response by mRECIST in advanced HCC predicts OS and thus can be considered as a candidate surrogate end-point. Further studies are needed to support this finding. Lay summary There is a need to identify surrogate end-points for overall survival in advanced hepatocellular carcinoma. We studied patients from the phase III BRISK trial, comparing brivanib treatment with placebo after sorafenib progression. We demonstrate that objective response is an independent predictor of survival and qualifies as a potential surrogate end-point for overall survival in this patient population. Clinical trial number NCT00825955.

Original languageEnglish (US)
Pages (from-to)1166-1172
Number of pages7
JournalJournal of Hepatology
Volume66
Issue number6
DOIs
StatePublished - Jun 2017

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Keywords

  • Advanced BCLC
  • Brivanib, mRECIST
  • Carcinoma, hepatocellular
  • Liver cancer
  • Objective response
  • Response evaluation criteria in solid tumours
  • Surrogate end-point

ASJC Scopus subject areas

  • Hepatology

Cite this

Lencioni, R., Montal, R., Torres, F., Park, J. W., Decaens, T., Raoul, J. L., Kudo, M., Chang, C., Ríos, J., Boige, V., Assenat, E., Kang, Y. K., Lim, H. Y., Walters, I., & Llovet, J. M. (2017). Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC. Journal of Hepatology, 66(6), 1166-1172. https://doi.org/10.1016/j.jhep.2017.01.012