Nutritionally variant streptococci causing endophthalmitis associated with intravitreal anti-vascular endothelial growth factor injection

Robert L. Steinmetz, Carsten Z. Steinmetz, Daniela P. Reyes-Capo, H. Logan Brooks, Jesse D. Sengillo, Darlene Miller, Harry W. Flynn

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To describe the clinical course and microbial properties of the first two reported cases of nutritionally variant Streptococci (Granulicatella adiacens and Abiotrophia defectiva) endophthalmitis following intravitreal anti-vascular endothelial growth factor injection (IVI). Observations: A 74 year-old female developed Granulicatella adiacens endophthalmitis following IVI. The patient underwent a pars plana vitrectomy and visual acuity recovered to 20/30 in six weeks. Similarly, an 88 year-old male developed Abiotrophia defectiva endophthalmitis after IVI. After a pars plana vitrectomy, the visual acuity recovered to 20/60 at five weeks. Conclusions and Importance: Endophthalmitis due to Streptococcus species has traditionally resulted in uniformly poor visual outcomes. However, nutritionally variant Streptococci, now reclassified as Granulicatella and Abiotrophia species, appear to have a less aggressive clinical course and better visual acuity outcomes. To the authors’ knowledge, these are the first reports of nutritionally variant Streptococci following IVI related endophthalmitis.

Original languageEnglish (US)
Article number101019
JournalAmerican Journal of Ophthalmology Case Reports
Volume21
DOIs
StatePublished - Mar 2021
Externally publishedYes

Keywords

  • Abiotrophia defectiva
  • Anti-VEGF
  • Endophthalmitis
  • Granulicatella adiacens
  • Intravitreal injection
  • Nutritionally variant streptococci

ASJC Scopus subject areas

  • Ophthalmology

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