Nutritional status and cardiac mass and function in children infected with the human immunodeficiency virus

Tracie L Miller, E. John Orav, Steven D. Colan, Steven E Lipshultz

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Malnutrition, skeletal muscle wasting, and changes in cardiac muscle mass and function have been described in children infected with the human immunodeficiency virus (HIV). This report analyzes the relation of nutritional status to cardiac muscle mass and function in HIV-infected children. Thirty-six children with symptomatic HIV infection underwent simultaneous anthropometric and echocardiographic evaluations before antiretroviral therapy or supplemental feedings. Nutritional measurements included weight, height, triceps skinfold thickness, and arm muscle circumference. Cardiac measurements included left ventricular mass, contractility, end-diastolic dimension, fractional shortening, blood pressure, and heart rate. In a cross-sectional analysis, children infected with HIV were significantly below age-adjusted standards for height (P = 0.0001), weight (P = 0.0001), triceps skinfold thickness (P = 0.001), and arm muscle circumference (P = 0.04). Left ventricular mass normalized to body surface area was below standard, but contractility was normal. Correlation analyses found an inverse relation between left ventricular mass and weight z score (r = -0.45, P = 0.01), height z score (r = -0.47, P = 0.006), and arm muscle circumference percentile (r = -0.51, P = 0.003). An inverse relation was also found between heart rate and weight z score (r = -0.47, P = 0.007) and arm muscle circumference percentile (r = -0.46, P = 0.007). In malnourished children with HIV infection, a paradoxical relation exists between nutritional status and cardiac muscle mass. The inverse relation between heart rate and nutritional status may suggest altered metabolic rates with possible increased sympathetic tone.

Original languageEnglish
Pages (from-to)660-664
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume66
Issue number3
StatePublished - Sep 1 1997
Externally publishedYes

Fingerprint

Human immunodeficiency virus
Nutritional Status
nutritional status
HIV
Weights and Measures
myocardium
Muscles
Skinfold Thickness
Myocardium
Heart Rate
heart rate
Virus Diseases
muscles
skinfold thickness
HIV infections
Body Surface Area
Malnutrition
Skeletal Muscle
cross-sectional studies
shortenings

Keywords

  • Children
  • Heart
  • HIV
  • Human immunodeficiency virus
  • Metabolism
  • Muscle mass
  • Nutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Nutritional status and cardiac mass and function in children infected with the human immunodeficiency virus. / Miller, Tracie L; Orav, E. John; Colan, Steven D.; Lipshultz, Steven E.

In: American Journal of Clinical Nutrition, Vol. 66, No. 3, 01.09.1997, p. 660-664.

Research output: Contribution to journalArticle

Miller, Tracie L ; Orav, E. John ; Colan, Steven D. ; Lipshultz, Steven E. / Nutritional status and cardiac mass and function in children infected with the human immunodeficiency virus. In: American Journal of Clinical Nutrition. 1997 ; Vol. 66, No. 3. pp. 660-664.
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