Abstract
Background. To investigate whether changes of nutritional status and behavior are associated with islet transplantation (ITx) and to assess their possible mechanisms. Methods. In this observational study, 52 subjects with type 1 diabetes, 30 of whom received ITx, underwent nutritional assessments. The study consisted of questionnaires complemented by a dietary intake recording, anthropometric measurements, and body composition analysis. Laboratory tests were also reviewed as part of the follow up. Results. After ITx, significant reductions in body weight (3.7 kg; P<0.0001), body mass index (1.39 kg/m 2; P<0.0001), waist circumference (3.96 cm; P=0.006), and fat weight (3.28 kg; P<0.01) were observed. The average consumption of carbohydrate and protein were also lower than pretransplant, together with some micronutrients (vitamins B12 and B6, zinc, and phosphorus). Insulin administration and changes in A1C were not associated with a significant change in anthropometric measurements. Subjects on exenatide after ITx showed significantly lower weight and body mass index than those not taking exenatide. Conclusions. ITx is associated with modifications in nutritional behavior and status. Drugs and health conditions are likely to be at least in part responsible for these changes, but a voluntary modification of eating habits by the patients also plays a role. Strict monitoring of nutritional parameters, counseling by experts in nutrition, and multivitamin/mineral supplement after ITx could be of benefit to the patients.
| Original language | English |
|---|---|
| Pages (from-to) | 501-506 |
| Number of pages | 6 |
| Journal | Transplantation |
| Volume | 85 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2008 |
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Keywords
- Behavior
- Islet transplantation
- Nutritional status
- Type 1 diabetes
ASJC Scopus subject areas
- Transplantation
- Immunology
Cite this
Nutritional status and behavior in subjects with type 1 diabetes, before and after islet transplantation. / Poggioli, Raffaella; Enfield, Gwen; Messinger, Shari; Faradji, Raquel N.; Tharavanij, Thipaporn; Pisani, Leandro; Cure, Pablo; Ponte, Gaston; Baidal, David; Froud, Tatiana; Ricordi, Camillo; Alejandro, Rodolfo.
In: Transplantation, Vol. 85, No. 4, 01.12.2008, p. 501-506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nutritional status and behavior in subjects with type 1 diabetes, before and after islet transplantation
AU - Poggioli, Raffaella
AU - Enfield, Gwen
AU - Messinger, Shari
AU - Faradji, Raquel N.
AU - Tharavanij, Thipaporn
AU - Pisani, Leandro
AU - Cure, Pablo
AU - Ponte, Gaston
AU - Baidal, David
AU - Froud, Tatiana
AU - Ricordi, Camillo
AU - Alejandro, Rodolfo
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Background. To investigate whether changes of nutritional status and behavior are associated with islet transplantation (ITx) and to assess their possible mechanisms. Methods. In this observational study, 52 subjects with type 1 diabetes, 30 of whom received ITx, underwent nutritional assessments. The study consisted of questionnaires complemented by a dietary intake recording, anthropometric measurements, and body composition analysis. Laboratory tests were also reviewed as part of the follow up. Results. After ITx, significant reductions in body weight (3.7 kg; P<0.0001), body mass index (1.39 kg/m 2; P<0.0001), waist circumference (3.96 cm; P=0.006), and fat weight (3.28 kg; P<0.01) were observed. The average consumption of carbohydrate and protein were also lower than pretransplant, together with some micronutrients (vitamins B12 and B6, zinc, and phosphorus). Insulin administration and changes in A1C were not associated with a significant change in anthropometric measurements. Subjects on exenatide after ITx showed significantly lower weight and body mass index than those not taking exenatide. Conclusions. ITx is associated with modifications in nutritional behavior and status. Drugs and health conditions are likely to be at least in part responsible for these changes, but a voluntary modification of eating habits by the patients also plays a role. Strict monitoring of nutritional parameters, counseling by experts in nutrition, and multivitamin/mineral supplement after ITx could be of benefit to the patients.
AB - Background. To investigate whether changes of nutritional status and behavior are associated with islet transplantation (ITx) and to assess their possible mechanisms. Methods. In this observational study, 52 subjects with type 1 diabetes, 30 of whom received ITx, underwent nutritional assessments. The study consisted of questionnaires complemented by a dietary intake recording, anthropometric measurements, and body composition analysis. Laboratory tests were also reviewed as part of the follow up. Results. After ITx, significant reductions in body weight (3.7 kg; P<0.0001), body mass index (1.39 kg/m 2; P<0.0001), waist circumference (3.96 cm; P=0.006), and fat weight (3.28 kg; P<0.01) were observed. The average consumption of carbohydrate and protein were also lower than pretransplant, together with some micronutrients (vitamins B12 and B6, zinc, and phosphorus). Insulin administration and changes in A1C were not associated with a significant change in anthropometric measurements. Subjects on exenatide after ITx showed significantly lower weight and body mass index than those not taking exenatide. Conclusions. ITx is associated with modifications in nutritional behavior and status. Drugs and health conditions are likely to be at least in part responsible for these changes, but a voluntary modification of eating habits by the patients also plays a role. Strict monitoring of nutritional parameters, counseling by experts in nutrition, and multivitamin/mineral supplement after ITx could be of benefit to the patients.
KW - Behavior
KW - Islet transplantation
KW - Nutritional status
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=44449089061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44449089061&partnerID=8YFLogxK
U2 - 10.1097/TP.0b013e3181629d7b
DO - 10.1097/TP.0b013e3181629d7b
M3 - Article
C2 - 18347527
AN - SCOPUS:44449089061
VL - 85
SP - 501
EP - 506
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 4
ER -