Nutritional status and behavior in subjects with type 1 diabetes, before and after islet transplantation

Raffaella Poggioli, Gwen Enfield, Shari Messinger, Raquel N. Faradji, Thipaporn Tharavanij, Leandro Pisani, Pablo Cure, Gaston Ponte, David Baidal, Tatiana Froud, Camillo Ricordi, Rodolfo Alejandro

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background. To investigate whether changes of nutritional status and behavior are associated with islet transplantation (ITx) and to assess their possible mechanisms. Methods. In this observational study, 52 subjects with type 1 diabetes, 30 of whom received ITx, underwent nutritional assessments. The study consisted of questionnaires complemented by a dietary intake recording, anthropometric measurements, and body composition analysis. Laboratory tests were also reviewed as part of the follow up. Results. After ITx, significant reductions in body weight (3.7 kg; P<0.0001), body mass index (1.39 kg/m 2; P<0.0001), waist circumference (3.96 cm; P=0.006), and fat weight (3.28 kg; P<0.01) were observed. The average consumption of carbohydrate and protein were also lower than pretransplant, together with some micronutrients (vitamins B12 and B6, zinc, and phosphorus). Insulin administration and changes in A1C were not associated with a significant change in anthropometric measurements. Subjects on exenatide after ITx showed significantly lower weight and body mass index than those not taking exenatide. Conclusions. ITx is associated with modifications in nutritional behavior and status. Drugs and health conditions are likely to be at least in part responsible for these changes, but a voluntary modification of eating habits by the patients also plays a role. Strict monitoring of nutritional parameters, counseling by experts in nutrition, and multivitamin/mineral supplement after ITx could be of benefit to the patients.

Original languageEnglish
Pages (from-to)501-506
Number of pages6
JournalTransplantation
Volume85
Issue number4
DOIs
StatePublished - Dec 1 2008

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Islets of Langerhans Transplantation
Nutritional Status
Type 1 Diabetes Mellitus
Body Mass Index
Weights and Measures
Nutrition Assessment
Vitamin B 6
Micronutrients
Waist Circumference
Feeding Behavior
Vitamin B 12
Body Composition
Phosphorus
Observational Studies
Minerals
Zinc
Counseling
Fats
Body Weight
Carbohydrates

Keywords

  • Behavior
  • Islet transplantation
  • Nutritional status
  • Type 1 diabetes

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Nutritional status and behavior in subjects with type 1 diabetes, before and after islet transplantation. / Poggioli, Raffaella; Enfield, Gwen; Messinger, Shari; Faradji, Raquel N.; Tharavanij, Thipaporn; Pisani, Leandro; Cure, Pablo; Ponte, Gaston; Baidal, David; Froud, Tatiana; Ricordi, Camillo; Alejandro, Rodolfo.

In: Transplantation, Vol. 85, No. 4, 01.12.2008, p. 501-506.

Research output: Contribution to journalArticle

Poggioli, Raffaella ; Enfield, Gwen ; Messinger, Shari ; Faradji, Raquel N. ; Tharavanij, Thipaporn ; Pisani, Leandro ; Cure, Pablo ; Ponte, Gaston ; Baidal, David ; Froud, Tatiana ; Ricordi, Camillo ; Alejandro, Rodolfo. / Nutritional status and behavior in subjects with type 1 diabetes, before and after islet transplantation. In: Transplantation. 2008 ; Vol. 85, No. 4. pp. 501-506.
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AU - Poggioli, Raffaella

AU - Enfield, Gwen

AU - Messinger, Shari

AU - Faradji, Raquel N.

AU - Tharavanij, Thipaporn

AU - Pisani, Leandro

AU - Cure, Pablo

AU - Ponte, Gaston

AU - Baidal, David

AU - Froud, Tatiana

AU - Ricordi, Camillo

AU - Alejandro, Rodolfo

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N2 - Background. To investigate whether changes of nutritional status and behavior are associated with islet transplantation (ITx) and to assess their possible mechanisms. Methods. In this observational study, 52 subjects with type 1 diabetes, 30 of whom received ITx, underwent nutritional assessments. The study consisted of questionnaires complemented by a dietary intake recording, anthropometric measurements, and body composition analysis. Laboratory tests were also reviewed as part of the follow up. Results. After ITx, significant reductions in body weight (3.7 kg; P<0.0001), body mass index (1.39 kg/m 2; P<0.0001), waist circumference (3.96 cm; P=0.006), and fat weight (3.28 kg; P<0.01) were observed. The average consumption of carbohydrate and protein were also lower than pretransplant, together with some micronutrients (vitamins B12 and B6, zinc, and phosphorus). Insulin administration and changes in A1C were not associated with a significant change in anthropometric measurements. Subjects on exenatide after ITx showed significantly lower weight and body mass index than those not taking exenatide. Conclusions. ITx is associated with modifications in nutritional behavior and status. Drugs and health conditions are likely to be at least in part responsible for these changes, but a voluntary modification of eating habits by the patients also plays a role. Strict monitoring of nutritional parameters, counseling by experts in nutrition, and multivitamin/mineral supplement after ITx could be of benefit to the patients.

AB - Background. To investigate whether changes of nutritional status and behavior are associated with islet transplantation (ITx) and to assess their possible mechanisms. Methods. In this observational study, 52 subjects with type 1 diabetes, 30 of whom received ITx, underwent nutritional assessments. The study consisted of questionnaires complemented by a dietary intake recording, anthropometric measurements, and body composition analysis. Laboratory tests were also reviewed as part of the follow up. Results. After ITx, significant reductions in body weight (3.7 kg; P<0.0001), body mass index (1.39 kg/m 2; P<0.0001), waist circumference (3.96 cm; P=0.006), and fat weight (3.28 kg; P<0.01) were observed. The average consumption of carbohydrate and protein were also lower than pretransplant, together with some micronutrients (vitamins B12 and B6, zinc, and phosphorus). Insulin administration and changes in A1C were not associated with a significant change in anthropometric measurements. Subjects on exenatide after ITx showed significantly lower weight and body mass index than those not taking exenatide. Conclusions. ITx is associated with modifications in nutritional behavior and status. Drugs and health conditions are likely to be at least in part responsible for these changes, but a voluntary modification of eating habits by the patients also plays a role. Strict monitoring of nutritional parameters, counseling by experts in nutrition, and multivitamin/mineral supplement after ITx could be of benefit to the patients.

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