Nutritional amblyopia - A histopathologic study with retrospective clinical correlation

W. E. Smiddy, W. R. Green

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


During a 10-year period ending in 1985, we observed atrophy of the maculopapillary bundle in both eyes of 25 cases examined post mortem. We retrospectively examined the clinical history and general autopsy findings for evidence of malnutrition. An adequate clinical history was obtained in 24 patients, and an autopsy was performed on 21 patients. Our review disclosed that all 25 patients had marked nutritional deprivation, most commonly from alcohol abuse (20 patients), advanced carcinoma (8 patients, 7 of whom were also alcohol abusers), and other malnutritional and disabling conditions (4 patients). A history of heavy smoking was documented in 11 patients. Our findings support the contention that dietary deficiency plays a role in the pathogenesis of the condition that in the past has been referred to as tobacco-alcohol amblyopia and more recently has been called nutritional amblyopia.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number5
StatePublished - Sep 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Nutritional amblyopia - A histopathologic study with retrospective clinical correlation'. Together they form a unique fingerprint.

Cite this