Numerical model for calculation of apparent diffusion coefficients (ADC) in permeable cylinders - Comparison with measured ADC in spinal cord white matter

John Ford, David B. Hackney

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

We have implemented a numerical method for calculation of the apparent diffusion coefficient (ADC) in spinal cord injury, which takes into account the distribution of axon diameters and permeability found in spinal cord white matter, as well as relative axonal volume. We propose a procedure for determining the status of axonal integrity from measured ADC values. These methods have been applied to a well characterized rat spinal cord injury model, affording a prediction of the increase in axonal permeability which is presumed to be closely related to functional deficit. ADC values are compared to those calculated from analytical formulas in the literature, and possible factors underlying the ADC behavior are explored. Calculated results indicate both axonal swelling and cell membrane permeability to be important factors contributing to ADC in traumatic spinal cord injury.

Original languageEnglish (US)
Pages (from-to)387-394
Number of pages8
JournalMagnetic Resonance in Medicine
Volume37
Issue number3
DOIs
StatePublished - Mar 1997
Externally publishedYes

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Keywords

  • diffusion, MR
  • spinal cord
  • white matter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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