Numb chin syndrome secondary to leptomeningeal carcinomatosis from gastric adenocarcinoma

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2 Scopus citations


Numb chin syndrome (NCS) can be a sign of malignancy. Its association with gastric adenocarcinoma is rare. We report a case of a 27-year-old Hispanic female that presented with complaint of left sided headache associated with numbness of the left side of chin and lower gingiva. Initial brain MRI, whole body gallium scan, high resolution CT of chest and elevated protein in the CSF were suggestive of sarcoidosis. She was treated with IV steroids with transient clinical improvement. Two weeks later, her symptoms worsened and further evaluation revealed the diagnosis of a poorly differentiated metastatic gastric adenocarcinoma with leptomeningeal involvement. This case report aims to emphasize the importance of identifying NCS as a possible indication of an underlying malignant condition. Reported cases of NCS associated with metastatic gastric adenocarcinoma are very rare.

Original languageEnglish (US)
Pages (from-to)E16-E20
JournalJournal of Gastrointestinal Oncology
Issue number2
StatePublished - 2015


  • Gastric adenocarcinoma
  • Leptomeningeal carcinomatosis (LMC)
  • Mental nerve neuropathy
  • Numb chin syndrome (NCS)
  • Sarcoidosis

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology


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