Nucleus reticularis lateralis involvement in the pressor component of the cerebral ischemic response

James R. Haselton, Carole L. Haselton, Pedro L. Vera, Howard H. Ellenberger, William G. LeBlanc, Neil Schneiderman, Philip M. McCabe

Research output: Contribution to journalArticle

7 Scopus citations


Lesions of the ventromedial portion of the nucleus reticularis lateralis (NRL) of the medulla oblongata in the rabbit significantly and markedly reduced the pressor component of the cerebral ischemic response (CIR) without altering vasomotor tone. Use of horseradish peroxidase as an anterograde and retrograde tracer indicated that the ventromedial NRL projects to the intermediolateral cell column (IML) of the upper thoracic spinal cord. Injections of glutamate into ventromedial NRL elevated blood pressure (BP), indicating that neuronal cell bodies in this area are capable of eliciting BP elevations when stimulated. These findings suggest that cell bodies in the ventromedial NRL are capable of eliciting pressor responses during the CIR via direct projections to sympathetic preganglionic cell bodies.

Original languageEnglish (US)
Pages (from-to)315-320
Number of pages6
JournalBrain Research
Issue number2
StatePublished - Jun 3 1985



  • blood pressure
  • cerebral ischemic response
  • glutamate
  • horseradish peroxidase
  • intermediolateral cell column
  • nucleus reticularis lateralis
  • rabbit

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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