Nucleotide excision repair in chromatin and the right of entry

Feng Gong, Youngho Kwon, Michael J. Smerdon

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

DNA is packaged with histones and other accessory proteins into chromatin in eukaryotic cells. It is well established that the assembly of DNA into chromatin affects induction of DNA damage as well as repair of the damage. How the DNA repair machinery detects a lesion and 'fixes it' in chromatin has been an intriguing question since the dawn of understanding DNA packaging in chromatin. Direct recognition/binding by damaged DNA binding proteins is one obvious tactic to detect a lesion. Rearrangement of chromatin structure during DNA repair was reported more than two decades ago. This early observation suggests that unfolding of chromatin structure may be required to facilitate DNA repair after lesions are detected. Cells can also exploit DNA processing events to assist DNA repair. Transcription coupled repair (TCR) is such an example. During TCR, an RNA polymerase blocked by a lesion, may act as a signal to recruit DNA repair machinery. Possible roles of histone modification enzymes, ATP-dependent chromatin remodeling complexes and chromatin assembly factors in DNA repair are discussed.

Original languageEnglish (US)
Pages (from-to)884-896
Number of pages13
JournalDNA Repair
Volume4
Issue number8
DOIs
StatePublished - Jul 28 2005
Externally publishedYes

Keywords

  • Cyclobutane pyrimidine dimer
  • Designed nucleosomes
  • Histones
  • Transcription coupled repair

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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