Nucleotide excision repair in chromatin and the right of entry

Feng Gong, Youngho Kwon, Michael J. Smerdon

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

DNA is packaged with histones and other accessory proteins into chromatin in eukaryotic cells. It is well established that the assembly of DNA into chromatin affects induction of DNA damage as well as repair of the damage. How the DNA repair machinery detects a lesion and 'fixes it' in chromatin has been an intriguing question since the dawn of understanding DNA packaging in chromatin. Direct recognition/binding by damaged DNA binding proteins is one obvious tactic to detect a lesion. Rearrangement of chromatin structure during DNA repair was reported more than two decades ago. This early observation suggests that unfolding of chromatin structure may be required to facilitate DNA repair after lesions are detected. Cells can also exploit DNA processing events to assist DNA repair. Transcription coupled repair (TCR) is such an example. During TCR, an RNA polymerase blocked by a lesion, may act as a signal to recruit DNA repair machinery. Possible roles of histone modification enzymes, ATP-dependent chromatin remodeling complexes and chromatin assembly factors in DNA repair are discussed.

Original languageEnglish
Pages (from-to)884-896
Number of pages13
JournalDNA Repair
Volume4
Issue number8
DOIs
StatePublished - Jul 28 2005
Externally publishedYes

Fingerprint

DNA Repair
Chromatin
Repair
Nucleotides
DNA
Chromatin Assembly and Disassembly
Histone Code
DNA Packaging
Transcription
Histones
Machinery
DNA-Binding Proteins
Eukaryotic Cells
DNA-Directed RNA Polymerases
DNA Damage
Adenosine Triphosphate
Observation
Accessories
Packaging
Enzymes

Keywords

  • Cyclobutane pyrimidine dimer
  • Designed nucleosomes
  • Histones
  • Transcription coupled repair

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Nucleotide excision repair in chromatin and the right of entry. / Gong, Feng; Kwon, Youngho; Smerdon, Michael J.

In: DNA Repair, Vol. 4, No. 8, 28.07.2005, p. 884-896.

Research output: Contribution to journalArticle

Gong, Feng ; Kwon, Youngho ; Smerdon, Michael J. / Nucleotide excision repair in chromatin and the right of entry. In: DNA Repair. 2005 ; Vol. 4, No. 8. pp. 884-896.
@article{73ab42d8812345e5ab3f90f393c66b9c,
title = "Nucleotide excision repair in chromatin and the right of entry",
abstract = "DNA is packaged with histones and other accessory proteins into chromatin in eukaryotic cells. It is well established that the assembly of DNA into chromatin affects induction of DNA damage as well as repair of the damage. How the DNA repair machinery detects a lesion and 'fixes it' in chromatin has been an intriguing question since the dawn of understanding DNA packaging in chromatin. Direct recognition/binding by damaged DNA binding proteins is one obvious tactic to detect a lesion. Rearrangement of chromatin structure during DNA repair was reported more than two decades ago. This early observation suggests that unfolding of chromatin structure may be required to facilitate DNA repair after lesions are detected. Cells can also exploit DNA processing events to assist DNA repair. Transcription coupled repair (TCR) is such an example. During TCR, an RNA polymerase blocked by a lesion, may act as a signal to recruit DNA repair machinery. Possible roles of histone modification enzymes, ATP-dependent chromatin remodeling complexes and chromatin assembly factors in DNA repair are discussed.",
keywords = "Cyclobutane pyrimidine dimer, Designed nucleosomes, Histones, Transcription coupled repair",
author = "Feng Gong and Youngho Kwon and Smerdon, {Michael J.}",
year = "2005",
month = "7",
day = "28",
doi = "10.1016/j.dnarep.2005.04.007",
language = "English",
volume = "4",
pages = "884--896",
journal = "DNA Repair",
issn = "1568-7864",
publisher = "Elsevier",
number = "8",

}

TY - JOUR

T1 - Nucleotide excision repair in chromatin and the right of entry

AU - Gong, Feng

AU - Kwon, Youngho

AU - Smerdon, Michael J.

PY - 2005/7/28

Y1 - 2005/7/28

N2 - DNA is packaged with histones and other accessory proteins into chromatin in eukaryotic cells. It is well established that the assembly of DNA into chromatin affects induction of DNA damage as well as repair of the damage. How the DNA repair machinery detects a lesion and 'fixes it' in chromatin has been an intriguing question since the dawn of understanding DNA packaging in chromatin. Direct recognition/binding by damaged DNA binding proteins is one obvious tactic to detect a lesion. Rearrangement of chromatin structure during DNA repair was reported more than two decades ago. This early observation suggests that unfolding of chromatin structure may be required to facilitate DNA repair after lesions are detected. Cells can also exploit DNA processing events to assist DNA repair. Transcription coupled repair (TCR) is such an example. During TCR, an RNA polymerase blocked by a lesion, may act as a signal to recruit DNA repair machinery. Possible roles of histone modification enzymes, ATP-dependent chromatin remodeling complexes and chromatin assembly factors in DNA repair are discussed.

AB - DNA is packaged with histones and other accessory proteins into chromatin in eukaryotic cells. It is well established that the assembly of DNA into chromatin affects induction of DNA damage as well as repair of the damage. How the DNA repair machinery detects a lesion and 'fixes it' in chromatin has been an intriguing question since the dawn of understanding DNA packaging in chromatin. Direct recognition/binding by damaged DNA binding proteins is one obvious tactic to detect a lesion. Rearrangement of chromatin structure during DNA repair was reported more than two decades ago. This early observation suggests that unfolding of chromatin structure may be required to facilitate DNA repair after lesions are detected. Cells can also exploit DNA processing events to assist DNA repair. Transcription coupled repair (TCR) is such an example. During TCR, an RNA polymerase blocked by a lesion, may act as a signal to recruit DNA repair machinery. Possible roles of histone modification enzymes, ATP-dependent chromatin remodeling complexes and chromatin assembly factors in DNA repair are discussed.

KW - Cyclobutane pyrimidine dimer

KW - Designed nucleosomes

KW - Histones

KW - Transcription coupled repair

UR - http://www.scopus.com/inward/record.url?scp=21844434955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21844434955&partnerID=8YFLogxK

U2 - 10.1016/j.dnarep.2005.04.007

DO - 10.1016/j.dnarep.2005.04.007

M3 - Article

VL - 4

SP - 884

EP - 896

JO - DNA Repair

JF - DNA Repair

SN - 1568-7864

IS - 8

ER -