Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics

Richard C. Becker, Thomas Povsic, Mauricio G. Cohen, Christopher P. Rusconi, Bruce Sullenger

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.

Original languageEnglish (US)
Pages (from-to)586-595
Number of pages10
JournalThrombosis and Haemostasis
Volume103
Issue number3
DOIs
StatePublished - Mar 1 2010

Keywords

  • Anticoagulant therapy
  • Nucleic acids
  • Protein-binding oligonucleotides
  • RNA and DNA aptamers

ASJC Scopus subject areas

  • Hematology

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