TY - JOUR
T1 - Nucleic acid aptamers as antithrombotic agents
T2 - Opportunities in extracellular therapeutics
AU - Becker, Richard C.
AU - Povsic, Thomas
AU - Cohen, Mauricio G.
AU - Rusconi, Christopher P.
AU - Sullenger, Bruce
PY - 2010/3
Y1 - 2010/3
N2 - Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.
AB - Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.
KW - Anticoagulant therapy
KW - Nucleic acids
KW - Protein-binding oligonucleotides
KW - RNA and DNA aptamers
UR - http://www.scopus.com/inward/record.url?scp=77749298357&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77749298357&partnerID=8YFLogxK
U2 - 10.1160/TH09-10-0716
DO - 10.1160/TH09-10-0716
M3 - Review article
C2 - 20135076
AN - SCOPUS:77749298357
VL - 103
SP - 586
EP - 595
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 3
ER -