Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics

Richard C. Becker; Thomas Povsic; Mauricio G. Cohen; Christopher P. Rusconi; Bruce Sullenger

doi:10.1160/TH09-10-0716

Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics

Richard C. Becker, Thomas Povsic, Mauricio G. Cohen, Christopher P. Rusconi, Bruce Sullenger

Medicine

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.

Original language	English (US)
Pages (from-to)	586-595
Number of pages	10
Journal	Thrombosis and Haemostasis
Volume	103
Issue number	3
DOIs	https://doi.org/10.1160/TH09-10-0716
State	Published - Mar 1 2010

Keywords

Anticoagulant therapy
Nucleic acids
Protein-binding oligonucleotides
RNA and DNA aptamers

ASJC Scopus subject areas

Hematology

Access to Document

10.1160/TH09-10-0716

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