Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics

Richard C. Becker, Thomas Povsic, Mauricio G Cohen, Christopher P. Rusconi, Bruce Sullenger

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.

Original languageEnglish
Pages (from-to)586-595
Number of pages10
JournalThrombosis and Haemostasis
Volume103
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Fibrinolytic Agents
Nucleic Acids
Blood Platelets
Thromboplastin
Biochemistry
Blood Vessels
Peptide Hydrolases
Therapeutics

Keywords

  • Anticoagulant therapy
  • Nucleic acids
  • Protein-binding oligonucleotides
  • RNA and DNA aptamers

ASJC Scopus subject areas

  • Hematology

Cite this

Nucleic acid aptamers as antithrombotic agents : Opportunities in extracellular therapeutics. / Becker, Richard C.; Povsic, Thomas; Cohen, Mauricio G; Rusconi, Christopher P.; Sullenger, Bruce.

In: Thrombosis and Haemostasis, Vol. 103, No. 3, 01.03.2010, p. 586-595.

Research output: Contribution to journalArticle

Becker, Richard C. ; Povsic, Thomas ; Cohen, Mauricio G ; Rusconi, Christopher P. ; Sullenger, Bruce. / Nucleic acid aptamers as antithrombotic agents : Opportunities in extracellular therapeutics. In: Thrombosis and Haemostasis. 2010 ; Vol. 103, No. 3. pp. 586-595.
@article{b6f5741304164c36a2ae7542a7ff6733,
title = "Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics",
abstract = "Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.",
keywords = "Anticoagulant therapy, Nucleic acids, Protein-binding oligonucleotides, RNA and DNA aptamers",
author = "Becker, {Richard C.} and Thomas Povsic and Cohen, {Mauricio G} and Rusconi, {Christopher P.} and Bruce Sullenger",
year = "2010",
month = "3",
day = "1",
doi = "10.1160/TH09-10-0716",
language = "English",
volume = "103",
pages = "586--595",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer GmbH",
number = "3",

}

TY - JOUR

T1 - Nucleic acid aptamers as antithrombotic agents

T2 - Opportunities in extracellular therapeutics

AU - Becker, Richard C.

AU - Povsic, Thomas

AU - Cohen, Mauricio G

AU - Rusconi, Christopher P.

AU - Sullenger, Bruce

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.

AB - Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.

KW - Anticoagulant therapy

KW - Nucleic acids

KW - Protein-binding oligonucleotides

KW - RNA and DNA aptamers

UR - http://www.scopus.com/inward/record.url?scp=77749298357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77749298357&partnerID=8YFLogxK

U2 - 10.1160/TH09-10-0716

DO - 10.1160/TH09-10-0716

M3 - Article

C2 - 20135076

AN - SCOPUS:77749298357

VL - 103

SP - 586

EP - 595

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 3

ER -