Nuclear prelamin a recognition factor and iron dysregulation in multiple sclerosis

Di Ding, Anddre Osmar Valdivia, Sanjoy K. Bhattacharya

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Dysregulation of iron metabolism and aberrant iron deposition has been associated with multiple sclerosis. However, the factors that contribute to this pathological state remain to be understood. In this study, human multiple sclerosis and mice brain samples were analyzed through mass spectrometry as well as histological and immunoblot techniques, which demonstrated that iron deposition is associated with increased levels of nuclear prelamin A recognition factor (NARF). NARF is a protein associated with the mitochondria which has also been linked to mitochondrial defects in multiple sclerosis. We report NARF to be associated in multiple sclerosis pathology and aberrant iron deposition.

Original languageEnglish (US)
Pages (from-to)275-282
Number of pages8
JournalMetabolic Brain Disease
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • Iron Metabolism
  • Multiple Sclerosis
  • NARF
  • Neurodegeneration

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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