Nuclear hormone receptor co-regulators

Obaid Yusuf Khan, Zafar Nawaz

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


The critical role of nuclear hormone receptor co-activators in gene expression has been extensively studied for the past few years. Co-regulators (co-activators and co-repressors) are known to utilize various enzymatic activities, in addition to molecular interactions, to modulate gene expression in response to hormonal signals. Recent studies that demonstrate the role of co-regulators in cancer and developmental disorders have revealed their possible role as targets of therapy. A greater understanding of the cellular physiology of co-regulators is necessary to explore the pathological ramifications of hormone-dependent diseases, and to discover new treatments.

Original languageEnglish (US)
Pages (from-to)692-701
Number of pages10
JournalCurrent Opinion in Drug Discovery and Development
Issue number5
StatePublished - Sep 2003
Externally publishedYes


  • Co-activators
  • Co-regulators
  • Co-repressors
  • Endocrine diseases
  • Gene transcription
  • Nuclear hormone receptors

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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