Nuclear factor-κB activation in Schwann cells regulates regeneration and remyelination

Paul D. Morton, Joshua T. Johnstone, Angel Y. Ramos, Daniel J. Liebl, Mary Bartlett Bunge, John R. Bethea

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Schwann cells (SCs) are crucial for peripheral nerve development and regeneration; however, the intrinsic regulatory mechanisms governing postinjury responses are poorly understood. Activation and deacetylation of nuclear factor-κB (NF- κB) in SCs have been implicated as prerequisites for peripheral nerve myelination. Using GFAP-IκBα-dn mice in which NF- κB transcriptional activation is inhibited in SCs, we found no discernable differences in the quantity or structure of myelinated axons in adult facial nerves. Following crush injury, axonal regeneration was impaired at 31 days and significantly enhanced at 65 days in transgenic animals. Compact remyelination and Remak bundle organization were significantly compromised at 31 days and restored by 65 days post injury. Together, these data indicate that inhibition of NF-κB activation in SCs transiently delays axonal regeneration and compact remyelination. Manipulating the temporal activation of nuclear factor-κB in Schwann cells may offer new therapeutic avenues for PNS and CNS regeneration.

Original languageEnglish (US)
Pages (from-to)639-650
Number of pages12
JournalGlia
Volume60
Issue number4
DOIs
StatePublished - Apr 1 2012

Keywords

  • Injury
  • Myelin
  • Nerve
  • Peripheral

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neurology

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    Morton, P. D., Johnstone, J. T., Ramos, A. Y., Liebl, D. J., Bunge, M. B., & Bethea, J. R. (2012). Nuclear factor-κB activation in Schwann cells regulates regeneration and remyelination. Glia, 60(4), 639-650. https://doi.org/10.1002/glia.22297