Nuclear bodies: A component of cell nuclei in hamster tissues and human tumors

Awtar Krishan, Betty G. Uzman, E. T. Hedley-Whyte

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Nuclear bodies which are seen as 1-1.5 μ large, fibrous whorls in some cell nuclei have been recorded in the present study in cells from a number of human tumors; lymph nodes, bone marrow and spleen of patients with leukemia and Hodgkin's disease; neurons in Dawson's subacute sclerosing leukoencephalitis; renal tubular cells in cytomegalic inclusion disease; and in cells from choroid plexus in two normal infants. In this study, large nuclear bodies were seen most frequently in the reticuloendothelial cells of thymus, lymph nodes, and spleen of hamsters carrying intraperitoneal transplants of human leukemic lymphoblasts. In many cases, interchromatinic granules and small masses of chromatin are seen associated with the fibrous nuclear bodies. On the basis of some preliminary histochemical staining and enzyme extractions, it appears probable that the fibrous nuclear bodies do not contain any DNA or RNA but may have proteins in their structure.

Original languageEnglish
Pages (from-to)563-572
Number of pages10
JournalJournal of Ultrasructure Research
Volume19
Issue number5-6
StatePublished - Aug 30 1967
Externally publishedYes

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Cell Nucleus
Cricetinae
Spleen
Lymph Nodes
Subacute Sclerosing Panencephalitis
Neoplasms
Choroid Plexus
Cytomegalovirus Infections
Hodgkin Disease
Thymus Gland
Chromatin
Leukemia
Cell Count
Bone Marrow
RNA
Staining and Labeling
Transplants
Kidney
Neurons
DNA

ASJC Scopus subject areas

  • Anatomy
  • Molecular Biology

Cite this

Krishan, A., Uzman, B. G., & Hedley-Whyte, E. T. (1967). Nuclear bodies: A component of cell nuclei in hamster tissues and human tumors. Journal of Ultrasructure Research, 19(5-6), 563-572.

Nuclear bodies : A component of cell nuclei in hamster tissues and human tumors. / Krishan, Awtar; Uzman, Betty G.; Hedley-Whyte, E. T.

In: Journal of Ultrasructure Research, Vol. 19, No. 5-6, 30.08.1967, p. 563-572.

Research output: Contribution to journalArticle

Krishan, A, Uzman, BG & Hedley-Whyte, ET 1967, 'Nuclear bodies: A component of cell nuclei in hamster tissues and human tumors', Journal of Ultrasructure Research, vol. 19, no. 5-6, pp. 563-572.
Krishan, Awtar ; Uzman, Betty G. ; Hedley-Whyte, E. T. / Nuclear bodies : A component of cell nuclei in hamster tissues and human tumors. In: Journal of Ultrasructure Research. 1967 ; Vol. 19, No. 5-6. pp. 563-572.
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