Abstract
Nuclear bodies which are seen as 1-1.5 μ large, fibrous whorls in some cell nuclei have been recorded in the present study in cells from a number of human tumors; lymph nodes, bone marrow and spleen of patients with leukemia and Hodgkin's disease; neurons in Dawson's subacute sclerosing leukoencephalitis; renal tubular cells in cytomegalic inclusion disease; and in cells from choroid plexus in two normal infants. In this study, large nuclear bodies were seen most frequently in the reticuloendothelial cells of thymus, lymph nodes, and spleen of hamsters carrying intraperitoneal transplants of human leukemic lymphoblasts. In many cases, interchromatinic granules and small masses of chromatin are seen associated with the fibrous nuclear bodies. On the basis of some preliminary histochemical staining and enzyme extractions, it appears probable that the fibrous nuclear bodies do not contain any DNA or RNA but may have proteins in their structure.
| Original language | English |
|---|---|
| Pages (from-to) | 563-572 |
| Number of pages | 10 |
| Journal | Journal of Ultrasructure Research |
| Volume | 19 |
| Issue number | 5-6 |
| State | Published - Aug 30 1967 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Anatomy
- Molecular Biology
Cite this
Nuclear bodies : A component of cell nuclei in hamster tissues and human tumors. / Krishan, Awtar; Uzman, Betty G.; Hedley-Whyte, E. T.
In: Journal of Ultrasructure Research, Vol. 19, No. 5-6, 30.08.1967, p. 563-572.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nuclear bodies
T2 - A component of cell nuclei in hamster tissues and human tumors
AU - Krishan, Awtar
AU - Uzman, Betty G.
AU - Hedley-Whyte, E. T.
PY - 1967/8/30
Y1 - 1967/8/30
N2 - Nuclear bodies which are seen as 1-1.5 μ large, fibrous whorls in some cell nuclei have been recorded in the present study in cells from a number of human tumors; lymph nodes, bone marrow and spleen of patients with leukemia and Hodgkin's disease; neurons in Dawson's subacute sclerosing leukoencephalitis; renal tubular cells in cytomegalic inclusion disease; and in cells from choroid plexus in two normal infants. In this study, large nuclear bodies were seen most frequently in the reticuloendothelial cells of thymus, lymph nodes, and spleen of hamsters carrying intraperitoneal transplants of human leukemic lymphoblasts. In many cases, interchromatinic granules and small masses of chromatin are seen associated with the fibrous nuclear bodies. On the basis of some preliminary histochemical staining and enzyme extractions, it appears probable that the fibrous nuclear bodies do not contain any DNA or RNA but may have proteins in their structure.
AB - Nuclear bodies which are seen as 1-1.5 μ large, fibrous whorls in some cell nuclei have been recorded in the present study in cells from a number of human tumors; lymph nodes, bone marrow and spleen of patients with leukemia and Hodgkin's disease; neurons in Dawson's subacute sclerosing leukoencephalitis; renal tubular cells in cytomegalic inclusion disease; and in cells from choroid plexus in two normal infants. In this study, large nuclear bodies were seen most frequently in the reticuloendothelial cells of thymus, lymph nodes, and spleen of hamsters carrying intraperitoneal transplants of human leukemic lymphoblasts. In many cases, interchromatinic granules and small masses of chromatin are seen associated with the fibrous nuclear bodies. On the basis of some preliminary histochemical staining and enzyme extractions, it appears probable that the fibrous nuclear bodies do not contain any DNA or RNA but may have proteins in their structure.
UR - http://www.scopus.com/inward/record.url?scp=0014221501&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0014221501&partnerID=8YFLogxK
M3 - Article
C2 - 4293465
AN - SCOPUS:0014221501
VL - 19
SP - 563
EP - 572
JO - Journal of Structural Biology
JF - Journal of Structural Biology
SN - 1047-8477
IS - 5-6
ER -