Nuclear and mitochondrial effects of adriamycin in singly isolated pulsating myocardial cells

Theodore J. Lampidis, Giuliana Moreno, Christian Salet, Francoise Vinzens

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Singly isolated mammalian myocardial cells beating in culture were utilized to investigate the possible mechanism of adriamycin cardiotoxicity. Two distinct effects were apparent 24 hours after treatment with 1.7 μg/ml of adriamycin: (1) nucleolar fragmentation, segregation, and chromatin clumping, as evidenced by phase contrast and electron microscopy; (2) inhibition of mitochondrial stimulatio, as revealed by u.v.-microbeam irradiation. The two effects, nuclear and mitochondrial, at early times seemed to be independent of each other. The ultrastructure of the mitochondria in treated cells appeared normal.

Original languageEnglish (US)
Pages (from-to)415-418,IN25-IN26,419-422
JournalJournal of Molecular and Cellular Cardiology
Volume11
Issue number4
DOIs
StatePublished - Apr 1979
Externally publishedYes

Keywords

  • Adriamycin
  • Isolated heart cells

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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