NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro

Brigitte Malgrange, Philippe P. Lefebvre, Didier Martin, Hinrich Staecker, Thomas R Van De Water, Gustave Moonen

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Confocal analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.

Original languageEnglish
Pages (from-to)2495-2499
Number of pages5
JournalNeuroReport
Volume7
Issue number15-17
StatePublished - Dec 14 1996
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Nerve Growth Factor
Neurons
Cochlea
Chemotactic Factors
Nerve Growth Factors
Hearing
In Vitro Techniques
Therapeutics

Keywords

  • Auditory neurones
  • Chemotropism
  • Cochlea
  • Growth factor therapy
  • Neurotrophin-3

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Malgrange, B., Lefebvre, P. P., Martin, D., Staecker, H., Van De Water, T. R., & Moonen, G. (1996). NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro. NeuroReport, 7(15-17), 2495-2499.

NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro. / Malgrange, Brigitte; Lefebvre, Philippe P.; Martin, Didier; Staecker, Hinrich; Van De Water, Thomas R; Moonen, Gustave.

In: NeuroReport, Vol. 7, No. 15-17, 14.12.1996, p. 2495-2499.

Research output: Contribution to journalArticle

Malgrange, B, Lefebvre, PP, Martin, D, Staecker, H, Van De Water, TR & Moonen, G 1996, 'NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro', NeuroReport, vol. 7, no. 15-17, pp. 2495-2499.
Malgrange B, Lefebvre PP, Martin D, Staecker H, Van De Water TR, Moonen G. NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro. NeuroReport. 1996 Dec 14;7(15-17):2495-2499.
Malgrange, Brigitte ; Lefebvre, Philippe P. ; Martin, Didier ; Staecker, Hinrich ; Van De Water, Thomas R ; Moonen, Gustave. / NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro. In: NeuroReport. 1996 ; Vol. 7, No. 15-17. pp. 2495-2499.
@article{60764354eb224ab388d55be86e79aa40,
title = "NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro",
abstract = "Confocal analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.",
keywords = "Auditory neurones, Chemotropism, Cochlea, Growth factor therapy, Neurotrophin-3",
author = "Brigitte Malgrange and Lefebvre, {Philippe P.} and Didier Martin and Hinrich Staecker and {Van De Water}, {Thomas R} and Gustave Moonen",
year = "1996",
month = "12",
day = "14",
language = "English",
volume = "7",
pages = "2495--2499",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "15-17",

}

TY - JOUR

T1 - NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro

AU - Malgrange, Brigitte

AU - Lefebvre, Philippe P.

AU - Martin, Didier

AU - Staecker, Hinrich

AU - Van De Water, Thomas R

AU - Moonen, Gustave

PY - 1996/12/14

Y1 - 1996/12/14

N2 - Confocal analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.

AB - Confocal analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.

KW - Auditory neurones

KW - Chemotropism

KW - Cochlea

KW - Growth factor therapy

KW - Neurotrophin-3

UR - http://www.scopus.com/inward/record.url?scp=0029842919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029842919&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 2495

EP - 2499

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 15-17

ER -