NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro

Brigitte Malgrange, Philippe P. Lefebvre, Didier Martin, Hinrich Staecker, Thomas R. Van De Water, Gustave Moonen

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Confocal analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.

Original languageEnglish (US)
Pages (from-to)2495-2499
Number of pages5
JournalNeuroreport
Volume7
Issue number15-17
StatePublished - Dec 14 1996

    Fingerprint

Keywords

  • Auditory neurones
  • Chemotropism
  • Cochlea
  • Growth factor therapy
  • Neurotrophin-3

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Malgrange, B., Lefebvre, P. P., Martin, D., Staecker, H., Van De Water, T. R., & Moonen, G. (1996). NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro. Neuroreport, 7(15-17), 2495-2499.