NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants

H. Staecker, W. Liu, C. Hartnick, P. Lefebvre, B. Malgrange, G. Moonen, Thomas R Van De Water

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Auditory neurons depend upon the integrity of both their peripheral (auditory hair cells) and central (cochlear nucleus) targets for survival. One proposed trophic mechanism is the production of neurotrophin-3 (NT-3) by auditory hair cells. Modiolus-spiral ganglion explants from adult rats that closely mirror cell-cell interactions and in vivo tissue relationships within this ganglion provide a model for testing trophic factors. Brain derived neurotrophic factor (BDNF), NT-3 and ciliary neurotrophic factor (CNTF) were tested for their ability, both individually and in combination, to support neuronal survival. NT-3 was the strongest individual promoter of survival, while CNTF (a cytokine) with NT-3 (a neurotrophin) was the most effective combination for promoting the survival of auditory neurons.

Original languageEnglish
Pages (from-to)1533-1537
Number of pages5
JournalNeuroReport
Volume6
Issue number11
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Ciliary Neurotrophic Factor
Spiral Ganglion
Neurotrophin 3
Auditory Hair Cells
Neurons
Cochlear Nucleus
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Cell Communication
Ganglia
Cytokines

Keywords

  • Auditory neurons
  • Cytokine
  • Injury
  • Neuronal degeneration
  • Neurotrophic effects
  • Neurotrophin
  • Pharmacologic therapy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Staecker, H., Liu, W., Hartnick, C., Lefebvre, P., Malgrange, B., Moonen, G., & Van De Water, T. R. (1995). NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants. NeuroReport, 6(11), 1533-1537.

NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants. / Staecker, H.; Liu, W.; Hartnick, C.; Lefebvre, P.; Malgrange, B.; Moonen, G.; Van De Water, Thomas R.

In: NeuroReport, Vol. 6, No. 11, 01.01.1995, p. 1533-1537.

Research output: Contribution to journalArticle

Staecker, H, Liu, W, Hartnick, C, Lefebvre, P, Malgrange, B, Moonen, G & Van De Water, TR 1995, 'NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants', NeuroReport, vol. 6, no. 11, pp. 1533-1537.
Staecker H, Liu W, Hartnick C, Lefebvre P, Malgrange B, Moonen G et al. NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants. NeuroReport. 1995 Jan 1;6(11):1533-1537.
Staecker, H. ; Liu, W. ; Hartnick, C. ; Lefebvre, P. ; Malgrange, B. ; Moonen, G. ; Van De Water, Thomas R. / NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants. In: NeuroReport. 1995 ; Vol. 6, No. 11. pp. 1533-1537.
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