NT-3 combined with cntf promotes survival of neurons in modiolus-spiral ganglion explants

Hinrich Staecker, Wei Liu, Chris Hartnick, Philippe Lefebvre, Brigitte Malgrange, Gustave Moonen, Thomas R. Van De Water

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Auditory neurons depend upon the integrity of both their peripheral (auditory hair cells) and central (cochlear nucleus) targets for survival. One proposed trophic mechanism is the production of neurotrophin-3 (NT-3) by auditory hair cells. Modiolus-spiral ganglion explants from adult rats that closely mirror cell-cell interactions and in vivo tissue relationships within this ganglion provide a model for testing trophic factors. Brain derived neurotrophic factor (BDNF), NT-3 and ciliary neurotrophic factor (CNTF) were tested for their ability, both individually and in combination, to support neuronal survival. NT-3 was the strongest individual promoter of survival, while CNTF (a cytokine) with NT-3 (a neurotrophin) was the most effective combination for promoting the survival of auditory neurons.

Original languageEnglish (US)
Pages (from-to)1533-1537
Number of pages5
JournalNeuroreport
Volume6
Issue number11
DOIs
StatePublished - Jul 1995

Keywords

  • Auditory neurons
  • Cytokine
  • Injury
  • Neuronal degeneration
  • Neurotrophic effects
  • Neurotrophin
  • Pharmacologic therapy

ASJC Scopus subject areas

  • Neuroscience(all)

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    Staecker, H., Liu, W., Hartnick, C., Lefebvre, P., Malgrange, B., Moonen, G., & Van De Water, T. R. (1995). NT-3 combined with cntf promotes survival of neurons in modiolus-spiral ganglion explants. Neuroreport, 6(11), 1533-1537. https://doi.org/10.1097/00001756-199507310-00017