NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic caenorhabditis elegans DEG/ENaC channels

Shaunak Kamat, Shrutika Yeola, Wenying Zhang, Laura Bianchi, Monica Driscoll

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Mechanisms that regulate plasma membrane expression of neuronally toxic DEG/ENaC channels are unclear., Results: Disruption of ER NRA-2, a Nicalin homolog, enhances C. Elegans MEC-10(d) DEG/ENaC neurotoxicity. Immunocytochemistry, TIRF imaging, and electrophysiological assays support that NRA-2 controls relative MEC-10(d) distribution between ER and cell surface to regulate channel activity levels., Conclusion: NRA-2 regulates surface expression of a mutant DEG/ENaC channel., Significance: NRA-2 Nicalin can modulate DEG/ENaC pathophysiology.

Original languageEnglish (US)
Pages (from-to)11916-11926
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
StatePublished - Apr 25 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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