Novel treatments schizophrenia: Targeting the neurotensin system

B. Kinkead, C. B. Nemeroff

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Evidence implicating neural circuits that utilize the neuropeptide transmitter neurotensin (NT) in the pathophysiology of schizophrenia and in the mechanism of action of antipsychotic drugs has previously been reviewed. The majority of evidence, taken together, supports the development of NT receptor agonists as novel antipsychotic drugs. This review comprehensively describes the NT receptor subtypes, discusses the development of NT receptor agonists and the behavioral effects of currently available NT receptor agonists. The compilation of data suggests that NT receptor agonists may represent a novel class of antipsychotic drugs for the treatment of schizophrenia.

Original languageEnglish (US)
Pages (from-to)205-218
Number of pages14
JournalCNS and Neurological Disorders - Drug Targets
Volume5
Issue number2
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

Keywords

  • Antipsychotic drug
  • Neuromedin N
  • Peptide
  • Schizophrenia
  • Xenin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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