Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes

Nicholas J. Maness, Jonah B. Sacha, Shari M. Piaskowski, Kimberly L. Weisgrau, Eva G. Rakasz, Gemma E. May, Matthew B. Buechler, Andrew D. Walsh, Nancy A. Wilson, David Watkins

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Understanding the correlates of immune protection against human immunodeficiency virus and simian immunodeficiency virus (SIV) will require defining the entire cellular immune response against the viruses. Here, we define two novel translation products from the SIV env mRNA that are targeted by the T-cell response in SIV-infected rhesus macaques. The shorter product is a subset of the larger product, which contains both the first exon of the Rev protein and a translated portion of the rev intron. Our data suggest that the translation of viral alternate reading frames may be an important source of T-cell epitopes, including epitopes normally derived from functional proteins.

Original languageEnglish
Pages (from-to)10280-10285
Number of pages6
JournalJournal of Virology
Volume83
Issue number19
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Fingerprint

Simian immunodeficiency virus
Simian Immunodeficiency Virus
T-Lymphocyte Epitopes
translation (genetics)
epitopes
T-lymphocytes
Messenger RNA
rev Gene Products
Reading Frames
Human immunodeficiency virus
Macaca mulatta
Cellular Immunity
cell-mediated immunity
Introns
exons
introns
Epitopes
Exons
proteins
HIV

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes. / Maness, Nicholas J.; Sacha, Jonah B.; Piaskowski, Shari M.; Weisgrau, Kimberly L.; Rakasz, Eva G.; May, Gemma E.; Buechler, Matthew B.; Walsh, Andrew D.; Wilson, Nancy A.; Watkins, David.

In: Journal of Virology, Vol. 83, No. 19, 01.10.2009, p. 10280-10285.

Research output: Contribution to journalArticle

Maness, NJ, Sacha, JB, Piaskowski, SM, Weisgrau, KL, Rakasz, EG, May, GE, Buechler, MB, Walsh, AD, Wilson, NA & Watkins, D 2009, 'Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes', Journal of Virology, vol. 83, no. 19, pp. 10280-10285. https://doi.org/10.1128/JVI.00138-09
Maness, Nicholas J. ; Sacha, Jonah B. ; Piaskowski, Shari M. ; Weisgrau, Kimberly L. ; Rakasz, Eva G. ; May, Gemma E. ; Buechler, Matthew B. ; Walsh, Andrew D. ; Wilson, Nancy A. ; Watkins, David. / Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes. In: Journal of Virology. 2009 ; Vol. 83, No. 19. pp. 10280-10285.
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