Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Lindsey Winer; Francisco I. Macedo; Abdullah Alfawaz; Antonio Sommariva; Giovanni Cecchetto; Holly L. Neville; Mecker G. Möller

doi:10.1097/MPH.0000000000001231

Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Lindsey Winer, Francisco I. Macedo, Abdullah Alfawaz, Antonio Sommariva, Giovanni Cecchetto, Holly L. Neville, Mecker G. Möller

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

The management of pediatric abdominopelvic angiosarcoma remains unclear due to limited clinical experience. Herein, we presented the first 2 pediatric patients with abdominal angiosarcoma who were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) after neoadjuvant therapy. The first patient is alive with recurrent disease at 1-year follow-up and the second patient remains disease free after 1 year. CRS and HIPEC should be considered as a therapeutic option in the management of pediatric abdominal angiosarcomas. A multi-institutional international shared registry is needed to further evaluate the role of CRS and HIPEC in inducing remission of abdominopelvic angiosarcomas in the pediatric population.

Original language	English (US)
Journal	Journal of Pediatric Hematology/Oncology
DOIs	https://doi.org/10.1097/MPH.0000000000001231
State	Accepted/In press - May 31 2018

Keywords

abdominal sarcoma
HIPEC
pediatric sarcoma
pelvic angiosarcoma
sarcoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0000000000001231

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Winer, L., Macedo, F. I., Alfawaz, A., Sommariva, A., Cecchetto, G., Neville, H. L., & Möller, M. G. (Accepted/In press). Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Journal of Pediatric Hematology/Oncology. https://doi.org/10.1097/MPH.0000000000001231

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abstract = "The management of pediatric abdominopelvic angiosarcoma remains unclear due to limited clinical experience. Herein, we presented the first 2 pediatric patients with abdominal angiosarcoma who were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) after neoadjuvant therapy. The first patient is alive with recurrent disease at 1-year follow-up and the second patient remains disease free after 1 year. CRS and HIPEC should be considered as a therapeutic option in the management of pediatric abdominal angiosarcomas. A multi-institutional international shared registry is needed to further evaluate the role of CRS and HIPEC in inducing remission of abdominopelvic angiosarcomas in the pediatric population.",

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AU - Neville, Holly L.

AU - Möller, Mecker G.

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