TY - JOUR
T1 - Novel targets for Parkinson's Disease
T2 - Addressing different therapeutic paradigms and conundrums
AU - Rane, Pallavi
AU - Sarmah, Deepaneeta
AU - Bhute, Shashikala
AU - Kaur, Harpreet
AU - Goswami, Avirag
AU - Kalia, Kiran
AU - Borah, Anupom
AU - Dave, Kunjan R
AU - Sharma, Nutan
AU - Bhattacharya, Pallab
PY - 2018/4/16
Y1 - 2018/4/16
N2 - Parkinson's disease (PD) is a neurodegenerative disease that is pathologically characterized by degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc).PD leads to clinical motor features that include rigidity, tremor and bradykinesia. Despite multiple available therapies for PD, the clinical features continue to progress, and patients suffer progressive disability. Many advances have been made in PD therapy which directly target the cause of the disease rather than providing symptomatic relief.A neuroprotective or disease modifying strategy that can slow or cease clinical progression and worsening disability remains as a major unmet medical need for PD management. The present review discusses potential novel therapies for PD thatincludesrecent interventions in the form of immunomodulatory techniques and stem cell therapy.Further, an introspective approach toidentify numerous other novel targets that can alleviate PD pathogenesis and enable physicians to practice multi-targeted therapy are discussed that may provide a ray of hope to PD patients in future.
AB - Parkinson's disease (PD) is a neurodegenerative disease that is pathologically characterized by degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc).PD leads to clinical motor features that include rigidity, tremor and bradykinesia. Despite multiple available therapies for PD, the clinical features continue to progress, and patients suffer progressive disability. Many advances have been made in PD therapy which directly target the cause of the disease rather than providing symptomatic relief.A neuroprotective or disease modifying strategy that can slow or cease clinical progression and worsening disability remains as a major unmet medical need for PD management. The present review discusses potential novel therapies for PD thatincludesrecent interventions in the form of immunomodulatory techniques and stem cell therapy.Further, an introspective approach toidentify numerous other novel targets that can alleviate PD pathogenesis and enable physicians to practice multi-targeted therapy are discussed that may provide a ray of hope to PD patients in future.
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U2 - 10.1021/acschemneuro.8b00180
DO - 10.1021/acschemneuro.8b00180
M3 - Article
C2 - 29957921
AN - SCOPUS:85049374890
JO - ACS Chemical Neuroscience
JF - ACS Chemical Neuroscience
SN - 1948-7193
ER -