Novel Targets for Parkinson's Disease: Addressing Different Therapeutic Paradigms and Conundrums

Pallavi Rane, Deepaneeta Sarmah, Shashikala Bhute, Harpreet Kaur, Avirag Goswami, Kiran Kalia, Anupom Borah, Kunjan R. Dave, Nutan Sharma, Pallab Bhattacharya

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Parkinson's disease (PD) is a neurodegenerative disease that is pathologically characterized by degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc). PD leads to clinical motor features that include rigidity, tremor, and bradykinesia. Despite multiple available therapies for PD, the clinical features continue to progress, and patients suffer progressive disability. Many advances have been made in PD therapy which directly target the cause of the disease rather than providing symptomatic relief. A neuroprotective or disease modifying strategy that can slow or cease clinical progression and worsening disability remains as a major unmet medical need for PD management. The present review discusses potential novel therapies for PD that include recent interventions in the form of immunomodulatory techniques and stem cell therapy. Further, an introspective approach to identify numerous other novel targets that can alleviate PD pathogenesis and enable physicians to practice multitargeted therapy and that may provide a ray of hope to PD patients in the future are discussed.

Original languageEnglish (US)
Pages (from-to)44-57
Number of pages14
JournalACS Chemical Neuroscience
Volume10
Issue number1
DOIs
StatePublished - Jan 16 2019

Keywords

  • Parkinson's disease
  • immunization
  • neuroinflammation
  • neuroprotection
  • neuroregeneration

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

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