Novel synthetic meshwork for glaucoma treatment. I. Design and preliminary in vitro and in vivo evaluation of various expanded poly(tetrafluoroethylene) materials

V. Jallet, S. E. Gautier, J. M. Parel, T. Matsui, I. Haefliger, H. Kondo, H. Kato, M. Savoldelli, Y. Pouliquen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A novel drainage implant for glaucoma filtering surgery (MESH) is proposed. After various expanded poly(tetrafluoroethylene) (e-PFTE) materials were evaluated, the feasibility and the short-term safety of the technique were assessed in this first pilot study in the rabbit. The porous structure and the in vitro resistance to aqueous flow of seven different e-PTFE membranes (5-80 μm average pore size) were compared. Eight Dutch pigmented rabbits were implanted with the T-shaped MESH implants made from either 20- or 50-μm average pore size e-PTFE membranes. Clinical examination, intraocular pressure (IOP) measurements, and histology analyses were performed over a period of 3 months. The contralateral nonoperated eyes served as controls. MESH implantation took less than 7 min. No postoperative hypotony, migration, or extrusion of the implant and no intraocular inflammation or infection occurred. A significant IOP reduction in the implanted eyes was obtained past postoperative day 21 with the 20-μm material implant. The drainage efficacy was correlated with the degree of colonization of the porous materials and the inner spacing of the implant as observed by histology. With a filtering patency 3 times longer than conventional trabeculectomy and laser sclerectomy, MESH surgery is a promising technique for glaucoma treatment. Further studies are underway to enhance the device efficacy and understand the mechanism of filtration.

Original languageEnglish (US)
Pages (from-to)260-269
Number of pages10
JournalJournal of Biomedical Materials Research
Volume47
Issue number2
DOIs
StatePublished - Sep 7 1999

Keywords

  • Biocompatibility
  • Expanded poly (tetrafluoroethylene)
  • Filtration surgery
  • Glaucoma
  • Ophthalmic implant

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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