Novel molecular targeted therapy for esophageal cancer

David S. Schrump, Dao M. Nguyen

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Esophageal cancers are highly lethal neoplasms which are generally refractory to conventional multidisciplinary interventions. Recent elucidation of the mechanisms of esophageal carcinogenesis, as well as preclinical studies utilizing chromatin remodeling agents and inhibitors of oncogene signaling in conjunction with conventional chemotherapeutic agents provide new opportunities for the development of potentially efficacious molecular targeted therapies for these malignancies.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalJournal of surgical oncology
Volume92
Issue number3
DOIs
StatePublished - Dec 1 2005

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Keywords

  • 5 Aza 2′deoxycytidine
  • Clinical trial
  • Depsipeptide FK228
  • DNA demethylating agents
  • Epigenetics
  • Esophageal cancer
  • HDAC inhibitors
  • Mitogen activated protein kinase

ASJC Scopus subject areas

  • Surgery
  • Oncology

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