Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections

Arthur R. Celestin, Stephen R. Odom, Konstantia Angelidou, Scott R. Evans, Raul Coimbra, Christopher A. Guidry, Joseph Cuschieri, Kaysie L. Banton, Patrick J. O'Neill, Reza Askari, Nicholas Namias, Therèse M. Duane, Jeffrey A. Claridge, E. Patchen Dellinger, Robert A. Sawyer, Charles H. Cook

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antimicrobial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of short-duration therapy for intra-abdominal infections.

Original languageEnglish (US)
Pages (from-to)1577-1579
Number of pages3
JournalClinical Infectious Diseases
Volume65
Issue number9
DOIs
StatePublished - Nov 1 2017

Keywords

  • antibiotic resistance
  • desirability of outcome ranking
  • duration of antibiotic therapy
  • intra-abdominal infection
  • surgical infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Celestin, A. R., Odom, S. R., Angelidou, K., Evans, S. R., Coimbra, R., Guidry, C. A., Cuschieri, J., Banton, K. L., O'Neill, P. J., Askari, R., Namias, N., Duane, T. M., Claridge, J. A., Dellinger, E. P., Sawyer, R. A., & Cook, C. H. (2017). Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections. Clinical Infectious Diseases, 65(9), 1577-1579. https://doi.org/10.1093/cid/cix569