Abstract
Background: The Rho GTPase guanine nucleotide exchange factor, Vav3, is overexpressed in human prostate cancer and enhances androgen receptor transcriptional activity. Results: Cdc37 is a novel Vav3 binding partner that enhances androgen receptor co-activation by Vav3 and increases prostate cancer cell proliferation. Conclusion: Vav3-Cdc37 interaction is required for maximal androgen receptor function and prostate cancer growth. Significance: Vav3-Cdc37 interaction is a potential therapeutic target for prostate cancer.
Original language | English (US) |
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Pages (from-to) | 5463-5474 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 8 |
DOIs | |
State | Published - Feb 22 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology