Abstract
Background: The Rho GTPase guanine nucleotide exchange factor, Vav3, is overexpressed in human prostate cancer and enhances androgen receptor transcriptional activity. Results: Cdc37 is a novel Vav3 binding partner that enhances androgen receptor co-activation by Vav3 and increases prostate cancer cell proliferation. Conclusion: Vav3-Cdc37 interaction is required for maximal androgen receptor function and prostate cancer growth. Significance: Vav3-Cdc37 interaction is a potential therapeutic target for prostate cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 5463-5474 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 8 |
| DOIs | |
| State | Published - Feb 22 2013 |
Fingerprint
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Novel interaction between the co-chaperone cdc37 and rho gtpase exchange factor vav3 promotes androgen receptor activity and prostate cancer growth. / Wu, Fayi; Peacock, Stephanie O.; Rao, Shuyun; Lemmon, Sandra; Burnstein, Kerry L.
In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5463-5474.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel interaction between the co-chaperone cdc37 and rho gtpase exchange factor vav3 promotes androgen receptor activity and prostate cancer growth
AU - Wu, Fayi
AU - Peacock, Stephanie O.
AU - Rao, Shuyun
AU - Lemmon, Sandra
AU - Burnstein, Kerry L
PY - 2013/2/22
Y1 - 2013/2/22
N2 - Background: The Rho GTPase guanine nucleotide exchange factor, Vav3, is overexpressed in human prostate cancer and enhances androgen receptor transcriptional activity. Results: Cdc37 is a novel Vav3 binding partner that enhances androgen receptor co-activation by Vav3 and increases prostate cancer cell proliferation. Conclusion: Vav3-Cdc37 interaction is required for maximal androgen receptor function and prostate cancer growth. Significance: Vav3-Cdc37 interaction is a potential therapeutic target for prostate cancer.
AB - Background: The Rho GTPase guanine nucleotide exchange factor, Vav3, is overexpressed in human prostate cancer and enhances androgen receptor transcriptional activity. Results: Cdc37 is a novel Vav3 binding partner that enhances androgen receptor co-activation by Vav3 and increases prostate cancer cell proliferation. Conclusion: Vav3-Cdc37 interaction is required for maximal androgen receptor function and prostate cancer growth. Significance: Vav3-Cdc37 interaction is a potential therapeutic target for prostate cancer.
UR - http://www.scopus.com/inward/record.url?scp=84874324273&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874324273&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.390963
DO - 10.1074/jbc.M112.390963
M3 - Article
C2 - 23281476
AN - SCOPUS:84874324273
VL - 288
SP - 5463
EP - 5474
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 8
ER -