Novel effect of serum on the incorporation of [2-3H]mannose into dolichol-bound carbohydrates and proteins

Susana G. Rossi, Victor Idoyaga-Vargas, Hector Carminatti

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In the present work we report a serum induced decrease in the rate of [2-3H]mannose incorporation into dolichol derivatives and proteins in the embryonic chick optic lobe. This novel effect of serum is widely distributed in sera from different species including man, and it seems to be a unique response of the central nervous system cells. It also appears not to be a generalized toxic effect since it does not affect mannose uptake and deoxyglucose phosphate accumulation. These findings acquire more physiological significance since the in vivo conditions were approached by the preservation of the topological relationship among the cells in each tissue particle and the maintenance of steady state labeling conditions.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalNeurochemistry International
Volume16
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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