Novel aspects on signal-transduction in the pancreatic β-cell

Per Olof Berggren, Ingo B. Leibiger

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The glucose-stimulus/insulin-secretion-coupling by the pancreatic β-cell, which guarantees the maintenance of glucose homeostasis in man, is regulated by a sophisticated interplay between glucose and a plethora of additional factors. Besides other nutrients, incretins, nerval innervation, systemic growth factors as well as autocrine and paracrine regulatory loops within the islet of Langerhans modulate the function of the insulin-producing β-cell. Although the modulatory role of these factors is well appreciated, the underlying molecular mechanisms involved remain poorly understood. However, in most cases β-cell membrane receptors coupled primarily to either G-proteins or tyrosine kinases, which subsequently activate respective second messenger cascades, are involved. In the present mini-review we will discuss the role of signaling through some of these receptor-operated effector systems in the light of pancreatic β-cell signal-transduction.

Original languageEnglish (US)
Pages (from-to)S7-S10
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume16
Issue numberSUPPL. 1
DOIs
StatePublished - Mar 2006

Keywords

  • Apolipoprotein CIII
  • Apoptosis
  • Ca channel
  • Inositol phosphates
  • Insulin receptor
  • Insulin release
  • Islet of Langerhans
  • Signal-transduction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism

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