Novel aspects on pancreatic beta-cell signal-transduction

Ingo B. Leibiger, Kerstin Brismar, Per Olof Berggren

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Pancreatic β-cells release insulin in appropriate amounts in order to keep blood glucose levels within physiological limits. Failure to do so leads to the most common metabolic disorder in man, diabetes mellitus. The glucose-stimulus/insulin-secretion coupling represents a sophisticated interplay between glucose and a variety of modulatory factors. These factors are provided by the blood supply (such as nutrients, vitamins, incretins etc.), the nerval innervations, cell-cell contacts as well as by paracrine and autocrine feedback loops within the pancreatic islet of Langerhans. However, the underlying mechanisms of their action remain poorly understood. In the present mini-review we discuss novel aspects of selective insulin signaling in the β-cell and novel insights into the role of higher inositol phosphates in insulin secretion. Finally we present a newly developed experimental platform that allows non-invasive and longitudinal in vivo imaging of pancreatic islet/β-cell biology at single-cell resolution.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume396
Issue number1
DOIs
StatePublished - May 21 2010
Externally publishedYes

Fingerprint

Signal transduction
Insulin-Secreting Cells
Signal Transduction
Islets of Langerhans
Insulin
Cytology
Incretins
Glucose
Inositol Phosphates
Medical problems
Vitamins
Nutrients
Blood Glucose
Blood
Cell Biology
Diabetes Mellitus
Feedback
Imaging techniques
Food

Keywords

  • Diabetes mellitus
  • In vivo imaging
  • Inositol phosphates
  • Insulin receptor
  • Insulin signal-transduction
  • Islet of Langerhans

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Novel aspects on pancreatic beta-cell signal-transduction. / Leibiger, Ingo B.; Brismar, Kerstin; Berggren, Per Olof.

In: Biochemical and Biophysical Research Communications, Vol. 396, No. 1, 21.05.2010, p. 111-115.

Research output: Contribution to journalArticle

Leibiger, Ingo B. ; Brismar, Kerstin ; Berggren, Per Olof. / Novel aspects on pancreatic beta-cell signal-transduction. In: Biochemical and Biophysical Research Communications. 2010 ; Vol. 396, No. 1. pp. 111-115.
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