Novel anticonvulsant action of chronic melatonin in gerbils

Thomas H. Champney, Jan Ailene C. Champney

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Melatonin, a hormone from the pineal gland, was tested for its anticonvulsant effects in male gerbils. Daily administration of melatonin (25 μg injection-1, s.c.) for ten weeks reduced the number and severity of seizures (total convulsion score: 7.67±1.83 in controls vs 2.47±0.90 in melatonin-injected animals, p<0.05) associated with the injection of the convulsant, pentylenetetrazol (PTZ, 60 mg kg-1, s.c.). However, neither 12 weeks of short photoperiod exposure (LD 10:14) nor biweekly administration of melatonin pellets altered PTZ-induced convulsions. Overall, melatonin-injected gerbils were better able to survive and respond to seizures than control animals. No melatonin-injected gerbils died during seizure induction (0/31) while 5 out of 33 control gerbils died after PTZ injection.The mechanism for melatonin's anticonvulsant effects could be due to a direct inhibitory action on neural activity or a conversion of melatonin to an anticonvulsant compound that resembles the kynurenines.

Original languageEnglish (US)
Pages (from-to)1152-1154
Number of pages3
JournalNeuroreport
Volume3
Issue number12
DOIs
StatePublished - Dec 1992
Externally publishedYes

Keywords

  • Anticonvulsant
  • Epilepsy
  • Gerbil
  • Melatonin
  • Pineal
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Novel anticonvulsant action of chronic melatonin in gerbils'. Together they form a unique fingerprint.

Cite this