TY - JOUR
T1 - Notch signalling in solid tumours
T2 - A little bit of everything but not all the time
AU - Ranganathan, Prathibha
AU - Weaver, Kelly L.
AU - Capobianco, Anthony J.
N1 - Funding Information:
The authors would like to thank members of the Capobianco laboratory for support and D. Robbins and J. Diez for critical reading of the manuscript and useful suggestions. Work in the authors’ laboratory is partly supported by grants from the US National Cancer Institute (ROI CA 83736) and the Samuel Waxman Foundation for Cancer Research, USA. The authors sincerely apologize to all their colleagues whose work has not been referenced in this article.
PY - 2011/5
Y1 - 2011/5
N2 - The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to an ever-widening understanding of cellular processes that are controlled or influenced by Notch signalling. As would be expected with such a pleiotropic pathway, the deregulation of Notch signalling leads to several pathological conditions, including cancer. A role for Notch is well established in haematological malignancies, and more recent studies have provided evidence for the importance of Notch activity in solid tumours. As it is thought to act as an oncogene in some cancers but as a tumour suppressor in others, the role of Notch in solid tumours seems to be highly context dependent.
AB - The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to an ever-widening understanding of cellular processes that are controlled or influenced by Notch signalling. As would be expected with such a pleiotropic pathway, the deregulation of Notch signalling leads to several pathological conditions, including cancer. A role for Notch is well established in haematological malignancies, and more recent studies have provided evidence for the importance of Notch activity in solid tumours. As it is thought to act as an oncogene in some cancers but as a tumour suppressor in others, the role of Notch in solid tumours seems to be highly context dependent.
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U2 - 10.1038/nrc3035
DO - 10.1038/nrc3035
M3 - Review article
C2 - 21508972
AN - SCOPUS:79955460636
VL - 11
SP - 338
EP - 351
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 5
ER -