Abstract
The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to an ever-widening understanding of cellular processes that are controlled or influenced by Notch signalling. As would be expected with such a pleiotropic pathway, the deregulation of Notch signalling leads to several pathological conditions, including cancer. A role for Notch is well established in haematological malignancies, and more recent studies have provided evidence for the importance of Notch activity in solid tumours. As it is thought to act as an oncogene in some cancers but as a tumour suppressor in others, the role of Notch in solid tumours seems to be highly context dependent.
| Original language | English |
|---|---|
| Pages (from-to) | 338-351 |
| Number of pages | 14 |
| Journal | Nature Reviews Cancer |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2011 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Notch signalling in solid tumours : A little bit of everything but not all the time. / Ranganathan, Prathibha; Weaver, Kelly L.; Capobianco, Anthony J.
In: Nature Reviews Cancer, Vol. 11, No. 5, 01.05.2011, p. 338-351.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Notch signalling in solid tumours
T2 - A little bit of everything but not all the time
AU - Ranganathan, Prathibha
AU - Weaver, Kelly L.
AU - Capobianco, Anthony J
PY - 2011/5/1
Y1 - 2011/5/1
N2 - The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to an ever-widening understanding of cellular processes that are controlled or influenced by Notch signalling. As would be expected with such a pleiotropic pathway, the deregulation of Notch signalling leads to several pathological conditions, including cancer. A role for Notch is well established in haematological malignancies, and more recent studies have provided evidence for the importance of Notch activity in solid tumours. As it is thought to act as an oncogene in some cancers but as a tumour suppressor in others, the role of Notch in solid tumours seems to be highly context dependent.
AB - The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to an ever-widening understanding of cellular processes that are controlled or influenced by Notch signalling. As would be expected with such a pleiotropic pathway, the deregulation of Notch signalling leads to several pathological conditions, including cancer. A role for Notch is well established in haematological malignancies, and more recent studies have provided evidence for the importance of Notch activity in solid tumours. As it is thought to act as an oncogene in some cancers but as a tumour suppressor in others, the role of Notch in solid tumours seems to be highly context dependent.
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UR - http://www.scopus.com/inward/citedby.url?scp=79955460636&partnerID=8YFLogxK
U2 - 10.1038/nrc3035
DO - 10.1038/nrc3035
M3 - Article
C2 - 21508972
AN - SCOPUS:79955460636
VL - 11
SP - 338
EP - 351
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 5
ER -