Normal taste acceptance and preference of PANX1 knockout mice

Michael G. Tordoff, Tiffany R. Aleman, Hillary T. Ellis, Makoto Ohmoto, Ichiro Matsumoto, Val I. Shestopalov, Claire H. Mitchell, J. Kevin Foskett, Rachel L. Poole

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.

Original languageEnglish (US)
Pages (from-to)453-459
Number of pages7
JournalChemical senses
Issue number7
StatePublished - Sep 2015


  • ATP release
  • CALHM1
  • Gustometer
  • Pannexin 1
  • Two-bottle choice test

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience


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