Normal taste acceptance and preference of PANX1 knockout mice

Michael G. Tordoff, Tiffany R. Aleman, Hillary T. Ellis, Makoto Ohmoto, Ichiro Matsumoto, Valery I Shestopalov, Claire H. Mitchell, J. Kevin Foskett, Rachel L. Poole

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.

Original languageEnglish (US)
Pages (from-to)453-459
Number of pages7
JournalChemical Senses
Volume40
Issue number7
DOIs
StatePublished - 2015

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Keywords

  • ATP release
  • CALHM1
  • Gustometer
  • Pannexin 1
  • Two-bottle choice test

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Tordoff, M. G., Aleman, T. R., Ellis, H. T., Ohmoto, M., Matsumoto, I., Shestopalov, V. I., Mitchell, C. H., Foskett, J. K., & Poole, R. L. (2015). Normal taste acceptance and preference of PANX1 knockout mice. Chemical Senses, 40(7), 453-459. https://doi.org/10.1093/chemse/bjv025