Abstract
Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 453-459 |
| Number of pages | 7 |
| Journal | Chemical senses |
| Volume | 40 |
| Issue number | 7 |
| DOIs | |
| State | Published - 2015 |
Keywords
- ATP release
- CALHM1
- Gustometer
- Pannexin 1
- Two-bottle choice test
ASJC Scopus subject areas
- Physiology
- Sensory Systems
- Physiology (medical)
- Behavioral Neuroscience
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Cite this
Tordoff, M. G., Aleman, T. R., Ellis, H. T., Ohmoto, M., Matsumoto, I., Shestopalov, V. I., Mitchell, C. H., Foskett, J. K., & Poole, R. L. (2015). Normal taste acceptance and preference of PANX1 knockout mice. Chemical senses, 40(7), 453-459. https://doi.org/10.1093/chemse/bjv025