Normal taste acceptance and preference of PANX1 knockout mice

Michael G. Tordoff; Tiffany R. Aleman; Hillary T. Ellis; Makoto Ohmoto; Ichiro Matsumoto; Valery I Shestopalov; Claire H. Mitchell; J. Kevin Foskett; Rachel L. Poole

doi:10.1093/chemse/bjv025

Normal taste acceptance and preference of PANX1 knockout mice

Michael G. Tordoff, Tiffany R. Aleman, Hillary T. Ellis, Makoto Ohmoto, Ichiro Matsumoto, Valery I Shestopalov, Claire H. Mitchell, J. Kevin Foskett, Rachel L. Poole

Ophthalmology

Research output: Contribution to journal › Article

18 Scopus citations

Abstract

Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.

Original language	English (US)
Pages (from-to)	453-459
Number of pages	7
Journal	Chemical Senses
Volume	40
Issue number	7
DOIs	https://doi.org/10.1093/chemse/bjv025
State	Published - 2015

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Keywords

ATP release
CALHM1
Gustometer
Pannexin 1
Two-bottle choice test

ASJC Scopus subject areas

Physiology
Sensory Systems
Physiology (medical)
Behavioral Neuroscience

Cite this

Tordoff, M. G., Aleman, T. R., Ellis, H. T., Ohmoto, M., Matsumoto, I., Shestopalov, V. I., Mitchell, C. H., Foskett, J. K., & Poole, R. L. (2015). Normal taste acceptance and preference of PANX1 knockout mice. Chemical Senses, 40(7), 453-459. https://doi.org/10.1093/chemse/bjv025

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AU - Shestopalov, Valery I

AU - Mitchell, Claire H.

AU - Foskett, J. Kevin

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Access to Document

10.1093/chemse/bjv025