Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors

Thomas Malek, Brian O. Porter, Elaine K. Codias, Paul Scibelli, Aixin Yu

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

The importance of IL-2Rβ function for immune regulation is highlighted by the severe impairment in lymphoid cell function in IL-2Rβ-deficient mice. It has been speculated that failed IL-2/IL-2R signaling in peripheral T cells causes the associated autoimmunity, imbalanced peripheral lymphoid homeostasis, and defective T cell function. This study explored the requirement for IL-2Rβ function in mature T lymphocytes. We show that transgenic thymic expression of the IL-2R β-chain in IL-2Rβ-deficient mice prevents lethal autoimmunity, restores normal production of B lymphocytes, and results in a peripheral T cell compartment that is responsive to triggering through the TCR, but not the IL-2R. The dysfunction of the IL-2R is illustrated by the near complete failure of mature T cells to proliferate to IL-2 in vitro and in vivo, to differentiate into CTL, and to up-regulate IL-2Rα expression. These data indicate that lymphoid homeostasis is largely maintained despite a nonfunctional IL-2R in mature T lymphocytes and suggest that IL-2Rβ provides an essential signal during thymic development to regulate self-reactivity.

Original languageEnglish
Pages (from-to)2905-2914
Number of pages10
JournalJournal of Immunology
Volume164
Issue number6
StatePublished - Mar 15 2000

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Interleukin-2 Receptors
Autoimmunity
Homeostasis
T-Lymphocytes
Interleukin-2
B-Lymphocytes
Up-Regulation
Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. / Malek, Thomas; Porter, Brian O.; Codias, Elaine K.; Scibelli, Paul; Yu, Aixin.

In: Journal of Immunology, Vol. 164, No. 6, 15.03.2000, p. 2905-2914.

Research output: Contribution to journalArticle

Malek, Thomas ; Porter, Brian O. ; Codias, Elaine K. ; Scibelli, Paul ; Yu, Aixin. / Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. In: Journal of Immunology. 2000 ; Vol. 164, No. 6. pp. 2905-2914.
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