Noribogaine generalization to the ibogaine Stimulus: Correlation with noribogaine concentration in rat brain

C. Zubaran, M. Shoaib, I. P. Stolerman, J. Pablo, D. C. Mash

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The discriminative stimulus effects of ibogaine and noribogaine in rats have been examined in relation to their concentrations in blood plasma and brain regions and to receptor systems through which they have been proposed to act. Rats were trained to discriminate ibogaine (10 mg/kg IP), the NMDA antagonist dizocilpine (0.08 mg/kg IP) or the κ-opioid agonist U50,488 (5 mg/kg IP) from vehicle in a standard two-lever operant conditioning procedure with a tandem VI-FR schedule of food reinforcement. Only rats trained on ibogaine generalized to noribogaine, which was approximately twice as potent as the parent compound. Noribogaine was detected in plasma and brain after administration of ibogaine and noribogaine. At the ED50 doses for the discriminative effect, the estimated concentrations of noribogaine in plasma, cerebral cortex, and striatum were similar regardless of whether ibogaine or noribogaine was administered. The findings suggest that the metabolite noribogaine may be devoid of NMDA antagonist and κ-opioid agonist discriminative effects and that it may play a major role in mediating the discriminative stimulus effect of ibogaine. Copyright (C) 1999 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalNeuropsychopharmacology
Volume21
Issue number1
DOIs
StatePublished - Jul 1 1999

Keywords

  • κ-opioids
  • Dizocilpine
  • Drug discrimination
  • Ibogaine
  • Noribogaine
  • Rats

ASJC Scopus subject areas

  • Pharmacology

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