Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta

Vivian Pijuan; Irene Litosch

doi:10.1016/S0006-291X(88)80831-3

Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta

Vivian Pijuan, Irene Litosch

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

Norepinephrine stimulated the rapid hydrolysis of [³H]phosphatidylinositol-4,5-bisphosphate in rat aorta with a maximal decrease of 30% within 60 sec of stimulation. Levels of [³H]phosphatidylinositol-4,5-bisphosphate returned to control by 5 min despite the continued presence of agonist. Hydrolysis of [³H]phosphatidylinositol-4,5-bisphosphate occurred concurrently with the formation of inositol phosphates. Inositol-tris and tetrakisphosphate levels were increased within 30 sec of agonist stimulation. Increases in inositol phosphate levels due to agonist were dose-dependent with half-maximal activation at 1 μM norepinephrine.

Original language	English
Pages (from-to)	240-245
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	156
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(88)80831-3
State	Published - Oct 14 1988
Externally published	Yes

Fingerprint

Inositol

Phosphatidylinositols

Aorta

Rats

Norepinephrine

Inositol Phosphates

Hydrolysis

Chemical activation

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Pijuan, V., & Litosch, I. (1988). Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta. Biochemical and Biophysical Research Communications, 156(1), 240-245. https://doi.org/10.1016/S0006-291X(88)80831-3

Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta. / Pijuan, Vivian; Litosch, Irene.

In: Biochemical and Biophysical Research Communications, Vol. 156, No. 1, 14.10.1988, p. 240-245.

Research output: Contribution to journal › Article

Pijuan, V & Litosch, I 1988, 'Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta', Biochemical and Biophysical Research Communications, vol. 156, no. 1, pp. 240-245. https://doi.org/10.1016/S0006-291X(88)80831-3

Pijuan V, Litosch I. Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta. Biochemical and Biophysical Research Communications. 1988 Oct 14;156(1):240-245. https://doi.org/10.1016/S0006-291X(88)80831-3

Pijuan, Vivian ; Litosch, Irene. / Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta. In: Biochemical and Biophysical Research Communications. 1988 ; Vol. 156, No. 1. pp. 240-245.

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10.1016/S0006-291X(88)80831-3