Abstract
Norepinephrine stimulated the rapid hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate in rat aorta with a maximal decrease of 30% within 60 sec of stimulation. Levels of [3H]phosphatidylinositol-4,5-bisphosphate returned to control by 5 min despite the continued presence of agonist. Hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate occurred concurrently with the formation of inositol phosphates. Inositol-tris and tetrakisphosphate levels were increased within 30 sec of agonist stimulation. Increases in inositol phosphate levels due to agonist were dose-dependent with half-maximal activation at 1 μM norepinephrine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 240-245 |
| Number of pages | 6 |
| Journal | Biochemical and biophysical research communications |
| Volume | 156 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 14 1988 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
Fingerprint Dive into the research topics of 'Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta'. Together they form a unique fingerprint.
Cite this
Pijuan, V., & Litosch, I. (1988). Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta. Biochemical and biophysical research communications, 156(1), 240-245. https://doi.org/10.1016/S0006-291X(88)80831-3