Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta

Vivian Pijuan; Irene Litosch

doi:10.1016/S0006-291X(88)80831-3

Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta

Vivian Pijuan, Irene Litosch

Molecular and Cellular Pharmacology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Norepinephrine stimulated the rapid hydrolysis of [³H]phosphatidylinositol-4,5-bisphosphate in rat aorta with a maximal decrease of 30% within 60 sec of stimulation. Levels of [³H]phosphatidylinositol-4,5-bisphosphate returned to control by 5 min despite the continued presence of agonist. Hydrolysis of [³H]phosphatidylinositol-4,5-bisphosphate occurred concurrently with the formation of inositol phosphates. Inositol-tris and tetrakisphosphate levels were increased within 30 sec of agonist stimulation. Increases in inositol phosphate levels due to agonist were dose-dependent with half-maximal activation at 1 μM norepinephrine.

Original language	English (US)
Pages (from-to)	240-245
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	156
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(88)80831-3
State	Published - Oct 14 1988

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta",

abstract = "Norepinephrine stimulated the rapid hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate in rat aorta with a maximal decrease of 30% within 60 sec of stimulation. Levels of [3H]phosphatidylinositol-4,5-bisphosphate returned to control by 5 min despite the continued presence of agonist. Hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate occurred concurrently with the formation of inositol phosphates. Inositol-tris and tetrakisphosphate levels were increased within 30 sec of agonist stimulation. Increases in inositol phosphate levels due to agonist were dose-dependent with half-maximal activation at 1 μM norepinephrine.",

author = "Vivian Pijuan and Irene Litosch",

note = "Funding Information: ACKNOWLEDGEMENTS This work was supported by an Established Investigator Award from the American Heart Association and with funds contributed from the AHA Florida Affiliate as well as by NIH DK-37007 and Lucille P. Markey Foundation. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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T1 - Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta

AU - Pijuan, Vivian

AU - Litosch, Irene

N1 - Funding Information: ACKNOWLEDGEMENTS This work was supported by an Established Investigator Award from the American Heart Association and with funds contributed from the AHA Florida Affiliate as well as by NIH DK-37007 and Lucille P. Markey Foundation. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1988/10/14

Y1 - 1988/10/14

N2 - Norepinephrine stimulated the rapid hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate in rat aorta with a maximal decrease of 30% within 60 sec of stimulation. Levels of [3H]phosphatidylinositol-4,5-bisphosphate returned to control by 5 min despite the continued presence of agonist. Hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate occurred concurrently with the formation of inositol phosphates. Inositol-tris and tetrakisphosphate levels were increased within 30 sec of agonist stimulation. Increases in inositol phosphate levels due to agonist were dose-dependent with half-maximal activation at 1 μM norepinephrine.

AB - Norepinephrine stimulated the rapid hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate in rat aorta with a maximal decrease of 30% within 60 sec of stimulation. Levels of [3H]phosphatidylinositol-4,5-bisphosphate returned to control by 5 min despite the continued presence of agonist. Hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate occurred concurrently with the formation of inositol phosphates. Inositol-tris and tetrakisphosphate levels were increased within 30 sec of agonist stimulation. Increases in inositol phosphate levels due to agonist were dose-dependent with half-maximal activation at 1 μM norepinephrine.

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Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta

Abstract

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