Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta

Vivian Pijuan, Irene Litosch

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Norepinephrine stimulated the rapid hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate in rat aorta with a maximal decrease of 30% within 60 sec of stimulation. Levels of [3H]phosphatidylinositol-4,5-bisphosphate returned to control by 5 min despite the continued presence of agonist. Hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate occurred concurrently with the formation of inositol phosphates. Inositol-tris and tetrakisphosphate levels were increased within 30 sec of agonist stimulation. Increases in inositol phosphate levels due to agonist were dose-dependent with half-maximal activation at 1 μM norepinephrine.

Original languageEnglish
Pages (from-to)240-245
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume156
Issue number1
DOIs
StatePublished - Oct 14 1988
Externally publishedYes

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Inositol
Phosphatidylinositols
Aorta
Rats
Norepinephrine
Inositol Phosphates
Hydrolysis
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta. / Pijuan, Vivian; Litosch, Irene.

In: Biochemical and Biophysical Research Communications, Vol. 156, No. 1, 14.10.1988, p. 240-245.

Research output: Contribution to journalArticle

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