Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta

Vivian Pijuan, Irene Litosch

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Norepinephrine stimulated the rapid hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate in rat aorta with a maximal decrease of 30% within 60 sec of stimulation. Levels of [3H]phosphatidylinositol-4,5-bisphosphate returned to control by 5 min despite the continued presence of agonist. Hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate occurred concurrently with the formation of inositol phosphates. Inositol-tris and tetrakisphosphate levels were increased within 30 sec of agonist stimulation. Increases in inositol phosphate levels due to agonist were dose-dependent with half-maximal activation at 1 μM norepinephrine.

Original languageEnglish (US)
Pages (from-to)240-245
Number of pages6
JournalBiochemical and biophysical research communications
Volume156
Issue number1
DOIs
StatePublished - Oct 14 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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