Norepinephrine response in early hiv infection

Mahendra Kumar, Robert Morgan, Jose Szapocznik, Carl Eisdorfer

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Norepinephrine response to a cold pressor test was investigated in 95 homosexual men in a longitudinal study of human immunodeficiency virus (HIV) infection. The baseline data obtained from 76 HIV + and 19 HIV-subjects are included in this report. After the insertion of a venicatheter and following a 30 min rest, subjects immersed one of their hands in ice water for 2 min, and serial blood samples were obtained for the determination of catecholamine levels. The results show that the norepinephrine response in HIV + subjects compared to that of HIV - subjects was blunted. Examination of the responses using linear and quadratic orthogonal polynomials suggested that these differences between the two groups were primarily a function of their rate of increase in norepinephrine levels. It was observed also that in HIV + subjects, norepinephrine level peaked earlier than that in HIV - subjects. The data suggest that autonomic dysfunction is present in the early stages of HIV infection.

Original languageEnglish (US)
Pages (from-to)782-786
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number8
StatePublished - Aug 1991


  • Autonomic reactivity
  • Cold-pressor test
  • HIV
  • Norepinephrine
  • Stress

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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